| 章小青.阻塞性睡眠呼吸暂停低通气综合征对3～7儿童生长发育的影响[J].浙江中西医结合杂志,2019,29(12): |
| 阻塞性睡眠呼吸暂停低通气综合征对3～7儿童生长发育的影响 |
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| 投稿时间：2019-02-19 修订日期：2019-11-08 |
| DOI： |
| 中文关键词: 睡眠呼吸暂停 阻塞性 氧减指数 生长发育 |
| 英文关键词: |
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| 中文摘要: |
| 【】 目的 了解3～7 岁非肥胖小儿阻塞性睡眠呼吸暂停低通气综合征(OSAHS)呼吸事件及低氧血症严重程度与疾病严重程度的相关性,进一步探讨该病对儿童生长发育的影响因素。 方法 通过对244例 3～7 岁非肥胖的OSAHS 患儿的身高、体重、PSG监测数据进行分析,首先统计呼吸暂停/低通气指数(AHI)、最低血氧饱和度(LSaO2)、最低动脉血氧饱和度持续时间占监测睡眠时间百分比(DLSaO2%)、≥4%氧减指数(≥4% ODI)在OSASH轻、中、重三组间的差异,再对三组患儿的身高、体重进行两两对比,并分别对患儿身高、体重与AHI、LSaO2、DLSaO2%、≥4% ODI进行相关性分析。 结果 ①AHI：重度组高于轻度组,差异有统计学意义(P=0.003)；LSaO2、DLSO2%：三组间差异均有统计学意义(P均=0.000)；②中度组、重度组身高均显著低于轻度组(P分别=0.000、0.002)；中度组、重度组体重均显著低于轻度组(P分别=0.003、0.024)；并且随病情严重程度增加,身高、体重均呈下降趋势；③身高与LSaO2、DLSO2%显著相关(r分别=0.196、-0.196,P分别=0.002、0.006),而与AHI及≥4%ODI未见显著相关；体重与LSaO2显著相关(r=0.146,P=0.022)。 结论 对3～7非肥胖的OSAHS患儿来说：①LSaO2与OSAHS的严重程度相关性更好；②OSAHS不同程度地影响儿童的生长发育,其主要相关因素是低氧血症；低氧血症对OSAHS患儿的病情严重程度判断更重要。 |
| 英文摘要: |
| 【】Objective The aim of this study is to investigate the correlation between respiratory events, severity of hypoxemia and severity of obstructive sleep apnea hypopnea syndrome (OSAHS) in non-obese children aged 3-7 years, and furthermore, to explore the influencing factors of OSAHS on children"s growth and development. Methods The height, weight and PSG monitoring data of 244 non-obese OSAHS children aged 3-7 year-old were analyzed. Firstly, we counted the difference of the apnea/hypopnea index (AHI), the lowest oxygen saturation (LSaO2), percentage of lowest arterial oxygen saturation duration to monitored sleep time (DLSaO2%), and ≥4% oxygen desaturation index (≥4% ODI) among the light, medium and heavy groups of OSASH. Secondly,we compared the height and weight in the 3 groups were compared among different groups. And thirdly,we compared the height and weight with AHI, LSaO2, DLSaO2 and ≥4% ODI. Finally, we analyzed the correlation between AHI, LSaO2, DLSaO2% and ≥4% ODI and the height and weight of the children. Results ①AHI of severe group was significantly lower than that of mild group (P=0.003), LSaO2、DLSO2% were significantly different in the 3 groups (P=0.000);②The height of moderate group and severe group was significantly lower than that of mild group (P=0.000, 0.002 respectively), and the weight of moderate group and severe group was significantly lower than that of mild group (P=0.003, 0.024 respectively). Height and weight both showed a downward trend with the severity of OSAHS. ③Height was significantly correlated with LSaO2 and DLSO 2% (r = 0.196, -0.196, P = 0.002, 0.006, respectively), but not with AHI and ≥4%ODI; and weight was significantly correlated with LSaO2 also(r =0.146, P = 0.022). Conclusion For 3-7 non-obese children with OSAHS, LSaO2 has better relative with the severity of OSAHS. OSAHS affects the growth and development of children in different degrees, mainly because of hypoxemia. Hypoxemia is more important than other factors to judge the severity of OSAHS. |
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