| 王仙伟,柯绍发,何欣威,雷虹,金笑平,张倩倩.无症状颈动脉狭窄(ACS)人群认知功能障碍与中医体质分布特点的研究[J].浙江中西医结合杂志,2019,29(12): |
| 无症状颈动脉狭窄(ACS)人群认知功能障碍与中医体质分布特点的研究 |
| Analysis on the relationship between Constitution of TCM and Cognitive impairment in asymptomatic carotid stenosis(ACS) Cases |
| 投稿时间：2019-06-11 修订日期：2019-08-05 |
| DOI： |
| 中文关键词: 无症状性颈动脉狭窄（ACS） 认知功能障碍 中医体质 |
| 英文关键词:Asymptomatic Carotid Stenosis(ACS) Cognitive impairment Constitution of TCM |
| 基金项目: |
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| 中文摘要: |
| 目的: 探讨无症状性颈动脉狭窄（Asymptomatic carotid stenosis，ACS）人群的中医体质分布与认知功能障碍的相关性，为中医药临床论治ACS提供理论依据。方法:筛选符合诊断标准的329例患者，分别填写中医体质分类与判定表，记录中医体质类型、中文版蒙特利尔认知评估量表(Montreal cognitive assessment，MoCA)和简易智能状态检查量(mini-mental state examination，MMSE)信息，运用统计学方法分析中医体质分布情况，以及其中医体质与认知功能障碍、颈动脉狭窄程度的相关性。结果: 中医体质按频数出现由大到小:单纯型以痰湿质（31例，12.97%）、血瘀质（22例，9.21%）、气虚质（16例，6.69%）为主，复合型以气虚痰湿质（19例，7.95%）、痰湿血瘀质（12例，5.02%）、阳虚痰湿质（11例，4.60%）为主；其中轻、中度ACS以痰湿质、气虚质、气虚痰湿质为主,重度及闭塞以血瘀质、痰湿血瘀质为主；痰湿血瘀质MMSE评分明显低于其余5组(p<0.05)，血瘀质、痰湿血瘀质MoCA评分明显低于其余4组(p<0.05)。结论：ACS人群中医体质分布规律与认知功能障碍、颈动脉的狭窄程度具有一定的相关性，认知功能障碍在体质类型为血瘀质及痰湿血瘀质中最明显。 |
| 英文摘要: |
| Objective: To study the relationship in patients with Asymptomatic carotid stenosis(ACS) between Constitution of TCM and cognitive impairment, in order to provide clinical support for the treatment of ACS.Methods: 329 patients who accord with diagnostic criteria of ACS; fill in the classification and decision tables of TCM constitution,recorded the information of Montreal cognitive assessment(MoCA) and mini-mental state examination(MMSE) and analysis the distribution of TCM constitution and the relationship between TCM constitution and cognitive impairment by statistical methods.Results: According to the distribution,the top three simple type of TCM constitution were phlegm-dampness (31cases,12.97%), blood stasis (22cases,9.21%) and Qi-deficiency (16cases,6.69%); top three complex type of TCM constitution were qi-deficiency,phlegm-dampness (19cases,7.95%),phlegm-dampness and blood stasis (12cases,5.02%) and yang-deficiency,phlegm-dampness (11cases,4.60%);Among them,TCM constitution of phlegm-dampness,Qi deficiency,phlegm-dampness,were mostly distributed in patients of Mild to moderate stenosis, TCM constitution of blood stasis, phlegm-dampness and blood stasis were mostly distributed in patients of severe stenosis and the occlusion; The MMSE score in TCM constitution of phlegm-dampness-blood stasis was significantly lower than the other five groups(p<0.05),while the MoCA score in TCM constitution of blood stasis and phlegm-dampness-blood stasis were significantly lower than the other four groups(p<0.05).Conclusion:The distribution of TCM constitution in patients of ACS is correlated with the degree of carotid artery stenosis and cognitive dysfunction, TCM constitution of blood stasis and phlegm-dampness-blood stasis have Cognitive dysfunction obviously. |
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