| .不明原因发热患者感染性疾病检出情况调查分析[J].浙江中西医结合杂志,2020,30(2): |
| 不明原因发热患者感染性疾病检出情况调查分析 |
| Investigation of the detection of infectious diseases in patients with fever of unknown origin |
| 投稿时间：2019-09-28 修订日期：2019-12-12 |
| DOI： |
| 中文关键词: 不明原因发热 感染性疾病 临床特点 |
| 英文关键词:fever of unknown origin infectious diseases clinical features |
| 基金项目: |
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| 中文摘要: |
| 目的 观察不明原因发热(FUO)患者的临床特点,调查分析患者感染性疾病检出情况,为未来FUO的防治提供参考。方法 分层整群抽样,回顾分析我院2017年6月至2019年6月收治的100例FUO患者临床资料,仔细阅览患者临床资料,记录其一般人口学资料,包括性别、年龄、体质量、受教育程度等,记录患者感染性疾病检出情况,分析其与非感染性疾病的不同,观察其临床特点。结果 100例FUO患者中确诊为感染性疾病者60例,发生率为60.00%,其他40例均为非感染性疾病,包括17例结缔组织病,10例杂病类,8例恶性肿瘤,5例病因未明；较非感染性疾病患者,感染性疾病患者男性占比多,热程短,畏寒、头痛是其主要症状表现,实验室检查主要表现为血清铁蛋白低表达、乳酸脱氢酶低表达、白蛋白高表达、碱性磷酸酶低表达,差异有统计学意义(P＜0.05)；经多因素非条件Logistic回归分析证实,血清铁蛋白是FUO患者感染性疾病独立预测因子,与疾病呈负相关(OR＞0,P＜0.05)。结论 FUO患者感染性疾病检出率高,以男性多见,患者常伴畏寒、头痛等症状表现,血清铁蛋白用于FUO患者感染性疾病与非感染性疾病的诊断鉴别中有一定价值。 |
| 英文摘要: |
| Objective To observe the clinical features of patients with fever of unknown origin (FUO), to investigate the detection of infectious diseases, and to provide reference for prevention and treatment of FUO. Methods The stratified cluster sampling was adopted. The clinical data of 100 patients with FUO from June 2017 to June 2019 were retrospectively analyzed. The clinical data of patients were carefully reviewed, and the general demographic data were recorded, including gender, age, body mass, level of education. The detection of infectious diseases was recorded, and its difference with non-infectious diseases was analyzed, and their clinical features were observed. Results Of the 100 patients with FUO, 60 cases were diagnosed as infectious diseases, the incidence rate was 60.00%, and the other 40 cases were non-infectious diseases, including 17 cases of connective tissue diseases, 10 cases of miscellaneous diseases, 8 cases of malignant tumors, and 5 cases of unknown causes; Compared with patients with non-infectious diseases, the male patients with infectious diseases account for a large proportion, short duration of fever, chills and headache were the main symptoms. Laboratory tests were mainly characterized by low expression of serum ferritin, low expression of lactate dehydrogenase, high expression of albumin and low expression of alkaline phosphatase (P<0.05); Multivariate unconditional Logistic regression analysis confirmed that serum ferritin was the independent predictor of infectious diseases in patients with FUO, which had negative correlation with disease (OR>0, P<0.05). Conclusion The detection rate of infectious diseases in patients with FUO is high, and it is more common in men. The patients often have symptoms such as chills and headache. Serum ferritin has certain value in the diagnosis and identification of infectious diseases and non-infectious diseases in FUO patients. |
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