| 周雯霏.多发性骨髓瘤合并李斯特菌感染一例并文献复习[J].浙江中西医结合杂志,2021,31(11): |
| 多发性骨髓瘤合并李斯特菌感染一例并文献复习 |
| Multiple myeloma complicated with Listeria monocytogenes meningitis:A case report |
| 投稿时间：2020-07-10 修订日期：2021-09-14 |
| DOI： |
| 中文关键词: 多发性骨髓瘤 自体干细胞移植术后 李斯特菌 |
| 英文关键词:Multiple myeloma, Post-ASCT, Listeria monocytogenes |
| 基金项目: |
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| 中文摘要: |
| 目的 探索多发性骨髓瘤患者李斯特菌感染的临床特征及治疗方案。方法 对一例自体干细胞移植术后的多发性骨髓瘤患者并发李斯特菌感染的临床特征、辅助检查、治疗方案及转归情况进行总结分析。结果 患者，52岁，确诊多发性骨髓瘤，自体干细胞移植术后7月，出现发热及消化道症状，治疗过程中出现中枢症状，血培养及脑脊液培养提示李斯特菌阳性，予美罗培南单药治疗效果不理想，改氨苄西林及利奈唑胺联合治疗2周，序贯利奈唑胺口服4周，达到临床治愈。结论 单核李斯特菌感染临床少见，多发性骨髓瘤患者免疫功能低下，合并李斯特菌感染需早期、足量、联合用药，以减少致死率。 |
| 英文摘要: |
| Objective To explore the clinical features and treatment of listeria monocytogenes infection.Method A rare case post-ASCT myeloma patient accompanied listeria monocytogenes infection was reported. Her clinical featurest, laboratory results and treatment were discussed. Results The patient is a 52-years-old woman, diagnosed with multiple myeloma,,7 months after autologous stem cell transplantation.She was admitted with a sudden fever, vomiting and diarrhea, subsequently onset headache. Then blood and cerebrospinal fluid culture was reported listeria monocytogenes. Giving a high dose of meropenem didn’t work. The illness improved after using linezolid and penicillin for 2 weeks,then removing on treatment with linezolid for 4 weeks.The patient finally cured. Conclusion The listeria monocytogenes infection was rare and easy to miss. The mortality and morbidity of patients accompanied with myoloma is really high. Consequently,once was diagnosed, it should be treated early, full dose, combination antibiotic treatment. |
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