| Purpose This study aims to explore the application value of sex hormone levels and thyroid hormone levels in patients with schizophrenia. Methods 130 patients with schizophrenia admitted to our hospital from August 2018 to May 2020 and 135 healthy people who came to our hospital for physical examination during the same period were selected as the research objects. Compare the levels of sex hormones and thyroid hormones between the two groups, analyze the comparison of sex hormones and thyroid hormone levels of different gender, age, course of disease, symptoms, and disease types in the schizophrenia group, and analyze the correlation between sex hormone levels, thyroid hormone levels and PANSS scores analysis. Results The E2 level of the schizophrenia group was lower than that of the healthy group, and the PRL level was higher than that of the healthy group, the difference was significant (P<0.05); the comparison of the FSH, T, LH levels of the two groups was not significant (P>0.05). The levels of TSH, FT3, and FT4 in the schizophrenia group were lower than those in the healthy group, and the difference was significant (P<0.05); compared with the levels of TT3 and TT4 in the two groups, the difference was not significant (P>0.05). In the schizophrenia group, the male E2, FSH, T, LH, and PRL were lower than females, and the age was less than 40 years, the disease course was less than 5 years, and the TSH levels of simple schizophrenia were lower than the age ≥40 years old and the disease course ≥5 Years and mixed schizophrenia, the difference is significant (P<0.05); TSH, FT3, FT4, TT3, TT4 in gender, E2, FSH, T, LH, PRL, FT3, FT4, TT3, TT4 in age, in the course of the disease FT3, TT3, TT4, E2, FSH, T, LH, PRL, FT3, FT4, TT3, TT4 in disease classification, the difference was not significant (P>0.05). In sex hormones, T level was positively correlated with positive symptom score and PANSS total score, E2 and PRL were negatively correlated with negative symptom score, and PRL was negatively correlated with positive symptom score (P<0.05). There was a negative correlation between FT3 in thyroid hormone and PANSS total score, negative symptom scale and general pathology scale (P＜0.05). Conclusion T, E2, PRL in sex hormones and FT3 in thyroid hormones have important diagnostic value in schizophrenia. |
