| 罗伊扬,王彬彬,江婷,丁诗意.基于数据挖掘的中药治疗化疗相关性呕吐用药规律分析[J].浙江中西医结合杂志,2021,31(12): |
| 基于数据挖掘的中药治疗化疗相关性呕吐用药规律分析 |
| Analysis on the Medication Rules of Chinese Medicine in Treating Chemotherapy induced Nausea and Vomiting Based on Data Mining |
| 投稿时间：2021-01-04 修订日期：2021-10-11 |
| DOI： |
| 中文关键词: 化疗相关性呕吐 古今医案云平台 中医药 用药规律 数据挖掘 |
| 英文关键词:Chemotherapy induced nausea and vomiting the Ancient and Modern Consilia Cloud Platform Traditional Chinese medicine Medication rules data mining |
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| 中文摘要: |
| 目的 通过“古今医案云台（V2.2.3）”探讨中医药治疗化疗相关性呕吐（chemotherapy induced nausea and vomiting，CINV）的用药规律。方法 通过搜索建库至2020年9月1日中国期刊全文数据库（CNKI）、万方数据知识服务平台、维普中文科技期刊数据库以及Pubmed外文数据库收录的中医药治疗CINV的相关文献，通过Excel建立数据库，利用古今医案云台软件进行频次分析、中药属性分析、关联分析、聚类分析等数据挖掘，探讨中医药治疗CINV的用药规律。结果 根据纳排标准，共纳入文献89篇，录入中药处方89首。使用频次前10位的处方为：旋覆代赭汤、半夏泻心汤、香砂六君子汤、小半夏加茯苓汤、温胆汤、参苓白术散、小半夏汤、橘皮竹茹汤、补脾益肾汤及附子理中汤。使用频次前10位的中药为茯苓、生姜、大枣、炙甘草、党参、半夏、陈皮、白术、甘草及赭石。药物四气多以温、平、微温，五味多以甘、辛、苦，归经多归属脾、胃、肺三经，功效多以功效为补中益气、燥湿化痰、降逆止呕为主。演化得出“陈皮-茯苓”、“白术-茯苓”、“旋覆花-赭石”、“砂仁-茯苓”、“白术-党参”等核心组合6个。结论 中药治疗CINV多从脾胃肺论治，药物多味甘性温，多以健脾益气、燥湿化痰、降逆止呕为法。 |
| 英文摘要: |
| OBJECTIVE To analyze the medication rules of Chinese Medicine in Treating Chemotherapy induced Nausea and Vomiting (CINV) based on the Ancient and Modern Consilia Cloud Platform V2.2.3.METHODS The related literature of treated by Chinese medicine were retrieved by searching China national knowledge infrastructure(CNKI),Wanfang Data Knowledge Service Platform, Weipu Data Knowledge Service Platform and PubMed from the establishment time of each database to September 1,2020. Excel was used to establish the database, and the database was input into the Ancient and Modern Consilia Cloud Platform. Data mining methods such as frequency analysis, attribute analysis of TCM, association rule analysis and cluster analysis were applied to analyze the data through the software to explore the medication rules in the treatment of CINV.RESULTS According to the included criteria and excluded criteria, a total of 89 articles were included, involving 89 Chinese medicine prescriptions. According to the systematic analysis，the top 10 prescriptions use frequency from high to low were Xuanfu Daizhe Decoction, Banxia Xiexin Decoction, Xiasha Liujunzi Decoction, Xiaobanxia plus Fuling Decoction, Wendan Decoction, Shenlingbaizhu Decoction, Xiaobanxia Decoction, Jupi Zhuru Decoction, Bupi Yishen Decoction and Fuzi Lizhong Decoction. The top 10 herbs use frequency from high to low were Poria Cocos, Zingiber Officinale Roscoe, Jujubae Fructus, prepared licorice, Codonopsis Radix, Arum Ternatum Thunb, Citrus Reticulata , Atractylodes Macrocephala Koidz , licorice and Ochre. Most of the herbs had warm, mild propterties and sweet, pungent, bitter flavors. And the channel tropism were the spleen, stomach and lung. The herbs usually had the actions of invigorating spleen-stomach and replenishing qi, drying damp and eliminating phlegm and descend reverse and stop vomiting. The analysis of association rules showed six core combinations include “Citrus Reticulata-Poria Cocos”, “Atractylodes Macrocephala Koidz-Poria Cocos”, “Inulae Flos-Ochre”, “Amomum Aurantiacum- Poria Cocos”, “Atractylodes Macrocephala Koidz- Codonopsis Radix”,etc. CONCLUSION Chinese medicine treatment of CINV is mainly based on spleen, stomach and lung, herbs are sweet and warm, focus on invigorating spleen-stomach and replenishing qi, drying damp and eliminating phlegm and descend reverse and stop vomiting. |
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