| 林超,章国晶,胡欣欣,马大正,孙云.顺应月经周期的中药及针刺疗法治疗排卵障碍性不孕症的疗效观察[J].浙江中西医结合杂志,2022,32(2): |
| 顺应月经周期的中药及针刺疗法治疗排卵障碍性不孕症的疗效观察 |
| Observation on the curative effect of traditional Chinese medicine and acupuncture in the treatment of ovulatory infertility |
| 投稿时间：2021-01-23 修订日期：2021-08-08 |
| DOI： |
| 中文关键词: 周期疗法 针刺 排卵障碍性不孕症 肾虚血瘀型 临床效果 性激素水平 |
| 英文关键词:cycle therapy acupuncture ovulatory infertility kidney deficiency and blood stasis clinical effect sex hormone level |
| 基金项目:2016年度浙江省中医药科学计划项目((2016ZA182));2017年度温州市科学计划项目(ZS2017019) |
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| 中文摘要: |
| 目的:探究排卵障碍性不孕症患者采用顺应月经周期的中药及针刺疗法的疗效。方法：选取我院2017年1月-2018年6月收治的134例肾虚血瘀型排卵障碍性不孕症患者入组作为研究对象,采用随机数字表法分为对照组(n=67例)和观察组(n=67例),对照组采用西药治疗干预,观察组在对照组基础上采用顺应月经周期的中药及针刺疗法,治疗6个月经周期后对患者效果进行评估,疗程后对患者完成2年随访,比较两组证候积分、性激素水平、成熟卵泡直径、内膜厚度、子宫内膜容受性、不良反应、排卵率及妊娠率。结果：对照组治疗后2周的五项证候积分均高于观察组(P<0.05)；对照组性激素P、E2、FSH三项水平均低于观察组(P<0.05)；而其LH水平高于观察组(P<0.05)；成熟卵泡直径、内膜厚度小于观察组(P<0.05)；PI及RI水平高于观察组(P<0.05)；两组用药期间不良反应发生率无统计意义(P>0.05)；妊娠率及排卵率低于观察组(P<0.05)。结论：中药周期疗法联合针刺用于排卵障碍性不孕症患者中有助于降低证候积分,可改善性激素水平,提高卵泡直径、内膜厚度,降低子宫内膜容受性,未增加不良反应发生率,获得较高的排卵率及妊娠率,值得推广应用。 |
| 英文摘要: |
| Objective: To observe the curative effect of traditional Chinese medicine and acupuncture in the treatment of ovulatory infertility. Methods: 134 patients with ovulatory dysfunction infertility (kidney deficiency and blood stasis type) from January 2017 to June 2018 were randomly divided into two groups, 67 cases in each group. The control group was treated with western medicine intervention, and the observation group was treated with traditional Chinese medicine cycle therapy combined with acupuncture on the basis of the control group. After 6 menstrual cycles, the effect of the patients was evaluated. After the treatment, the patients were followed up for 2 years. The syndrome score, sex hormone level, mature follicle diameter, endometrial thickness, endometrial receptivity, adverse reactions, ovulation rate and pregnancy rate of the two groups were compared. Results: two weeks after treatment, the scores of infertility, dysmenorrhea, abnormal menstrual color, low back acid and dizziness with tinnitus in the observation group were lower than those in the control group (P < 0.05); the levels of sex hormone P, E2 and FSH in the observation group were higher than those in the control group (P < 0.05); the level of LH in the observation group was lower than that in the control group (P < 0.05); the diameter and intimal thickness of mature follicles in the observation group were larger than those in the control group (P < 0.05); the PI in the observation group was higher than that in the control group (P < 0.05) The incidence of nausea and vomiting, diarrhea and constipation, rash and abnormal liver and kidney in the two groups had no statistical significance (P > 0.05); the pregnancy rate and ovulation rate in the observation group were higher than those in the control group (P < 0.05). Conclusion: Traditional Chinese medicine cycle therapy combined with acupuncture is helpful to reduce syndrome score, improve sex hormone level, increase follicle diameter and endometrial thickness, reduce endometrial receptivity, without increasing the incidence of adverse reactions, and obtain higher ovulation rate and pregnancy rate, which is worthy of popularization and application. |
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