| 吴克钗.慢性肾小球肾炎患者血浆suPAR、Cys-C表达与肾功能及预后的相关性研究[J].浙江中西医结合杂志,2022,32(2): |
| 慢性肾小球肾炎患者血浆suPAR、Cys-C表达与肾功能及预后的相关性研究 |
| Relationship between plasma suPAR, Cys-C expression and renal function, prognosis in patients with chronic glomerulonephritis |
| 投稿时间：2021-03-25 修订日期：2021-05-13 |
| DOI： |
| 中文关键词: 慢性肾小球肾炎 可溶性尿激酶型纤溶酶原激活物受体 胱抑素C |
| 英文关键词:chronic glomerulonephritis soluble urokinase-type plasminogen activator receptor Cystatin C |
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| 中文摘要: |
| 目的：分析慢性肾小球肾炎（CGN）患者血浆可溶性尿激酶型纤溶酶原激活物受体（suPAR）、胱抑素C（Cys-C）表达与肾功能及预后的相关性。方法：选取2016年11月-2018年12月温州医科大学附属苍南医院肾内科收治的CGN患者100例作为研究对象（试验组）；另选取同期在本院进行体检的健康人90例作为对照组。对所有CGN患者进行2年随访，根据预后情况分为缓解组（89例）和慢性肾功能衰竭组（11例）。收集受试者一般资料；酶联免疫吸附（ELISA）法检测受试者血浆suPAR、Cys-C水平；Pearson法分析血浆suPAR、Cys-C水平与尿素氮（BUN）、血清肌酐（SCr）、尿酸（UA）的相关性；通过COX比例风险模型分析影响CGN患者预后的因素。结果：与对照组相比，试验组血清BUN、SCr、UA和血浆中suPAR、Cys-C水平均升高（P＜0.05）。与缓解组相比，慢性肾功能衰竭组血浆中suPAR、Cys-C水平均升高（P＜0.05）。Pearson法分析相关性显示，CGN患者血浆suPAR、Cys-C水平与BUN、SCr、UA均呈正相关（P<0.05）。多因素COX分析显示，suPAR、Cys-C水平偏高均是CGN患者不良预后的危险因素（HR=2.598、3.342，P＜0.05）。结论：suPAR、Cys-C在CGN患者血浆中水平升高，与CGN患者预后不良有关，是CGN患者发生慢性肾功能衰竭的危险因素，可能作为潜在的诊断CGN和慢性肾功能衰竭的标志物。 |
| 英文摘要: |
| Objective: To analyze the correlation between the expression of plasma soluble urokinase-type plasminogen activator receptor (suPAR), Cystatin C (Cys-C) and renal function, prognosis in patients with chronic glomerulonephritis (CGN). Methods: A total of 100 cases of CGN patients in department of Nephrology, Cangnan Hospital Affiliated to Wenzhou Medical University from November 2016 to December 2018 were selected as the research objects (experimental group); 90 healthy people who had physical examination in our hospital at the same time were selected as the control group. All patients were followed-up for 2 years. According to the prognosis, they were divided into remission group (89 cases) and chronic renal failure group (11 cases). General data of the subjects were collected. The plasma levels of suPAR and Cys-C were detected by enzyme-linked immunosorbent assay (ELISA). Pearson method was used to analyze the correlation of plasma suPAR and Cys-C levels with urea nitrogen (BUN), serum creatinine (SCr) and uric acid (UA); COX proportional hazard model was used to analyze the prognostic factors of patients with CGN. Results: Compared with those in the control group, the levels of serum BUN, SCr, UA and plasma suPAR, Cys-C in the experimental group were higher (P < 0.05). Compared with those in the remission group, the plasma levels of suPAR and Cys-C in chronic renal failure group were higher (P < 0.05). Pearson analysis showed that plasma suPAR and Cys-C levels in patients with CGN were positively correlated with BUN, SCr and UA (P < 0.05). Multivariate COX analysis showed that high levels of suPAR and Cys-C were risk factors for poor prognosis in patients with CGN (HR = 2.598, 3.342, P < 0.05). Conclusion: The plasma levels of suPAR and Cys-C are increased in patients with CGN, they are associated with poor prognosis of patients with CGN, and are risk factors for chronic renal failure in patients with CGN. They may be potential markers for the diagnosis of CGN and chronic renal failure. |
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