| 刘敏,詹程胹,施琳琳,赵丽,张兆林,蒋霞,陈建永.理气通便合剂联合莫沙必利治疗功能性便秘的有效性分析[J].浙江中西医结合杂志,2021,31(10): |
| 理气通便合剂联合莫沙必利治疗功能性便秘的有效性分析 |
| Efficacy of liqitongbianheji combined with moxabilli in the treatment of functional constipation |
| 投稿时间：2021-04-18 修订日期：2021-08-12 |
| DOI： |
| 中文关键词: 功能性便秘 理气通便合剂 莫沙必利 有效性 |
| 英文关键词:Functional constipation Liqitongbianheji Moxabilli Effectivenes |
| 基金项目:杭州市科技发展计划 |
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| 中文摘要: |
| 【摘要】目的：探讨理气通便合剂联合莫沙必利治疗功能性便秘的有效性。方法：便利抽样法选取2019年1月-2020年6月本院120例功能性便秘患者，平行对照法分为研究组与对照组。研究组给予理气通便合剂（50mL /次，2次/d）联合莫沙必利（5mg/次，3次/d）治疗，疗程为4周；对照组单纯采用莫沙必利（5mg/次，3次/d）治疗，疗程为4周。对比两组排便指标变化、临床症状评分变化、临床疗效及复发情况。结果：①治疗后，研究组每周排便次数明显多于对照组，而排便时间明显短于对照组，大便性状评分、排便难易程度评分明显低于对照组（P＜0.05）；②治疗后，临床症状排便不尽感、腹痛、腹胀评分明显低于对照组，差异有统计学意义（t=14.833，P=0.000）；③研究组总有效率（98.33%）高于对照组（86.67%），差异有统计学意义（χ2=4.324，P=0.038）；④随访2个月，研究组复发率（1.67%）低于对照组（15.00%），差异有统计学意义（χ2=6.982，P=0.008）。结论：功能性便秘患者治疗中联合应用理气通便合剂与莫沙必利，可明显改善患者临床便秘症状及临床伴随症状，疗效显著可靠，且能降低复发风险，值得临床推广。 |
| 英文摘要: |
| [Abstract]Objective:To explore the efficacy of liqitongbianheji combined with moxabilli in the treatment of functional constipation.Methods: The convenience sampling method selected 120 patients with functional constipation from January 2019 to June 2020 in our hospital.Parallel control was divided into study group and control group.The study group was given liqitongbianheji (50mL/time, 2 times /d) combined with moxabilli (5mg/ time, 3 times /d) for 4 weeks.In the control group, moxabilli (5mg/ time, 3 times /d) was treated only, with a course of 4 weeks.The defecation time, abnormal stool symptom score, clinical curative effect and recurrence were compared between the two groups.Results: ①After treatment, the number of defecation per week in the study group was significantly more than that in the control group, while the defecation time was significantly shorter than that in the control group, and the defecation character score and defecation difficulty score were significantly lower than those in the control group (P < 0.05). ② after treatment, the clinical symptoms of incomplete defecation, abdominal pain and abdominal distension were significantly lower than those in the control group, and the difference was statistically significant (t=14.833, P=0.000);③The overall efficiency rate of the study group (98.33%) was higher than that of the control group (86.67%), and the difference was statistically significant (χ2=4.324, P=0.038);④After 2 months of follow-up, the recurrence rate of the study group (1.67%) was lower than that of the control group (15.00%), and the difference was statistically significant (χ2=6.982, P=0.008).Conclusion: The combined use of recuperating qi tongbian mixture and moxabilli in the treatment of patients with functional constipation can shorten the time of first defecation, relieve symptoms, enhance curative effect and reduce the risk of recurrence, which is worthy of clinical promotion. |
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