| 刘信信,顾艳霞,蔡璐,刘强.基于心肌纤维化防治心力衰竭的研究进展[J].浙江中西医结合杂志,2022,32(3): |
| 基于心肌纤维化防治心力衰竭的研究进展 |
| Research progress of prevention and treatment of heart failure based on myocardial fibrosis |
| 投稿时间：2021-04-19 修订日期：2021-12-24 |
| DOI： |
| 中文关键词: 心肌纤维化 发病机制 心室重构 抗心衰药物 |
| 英文关键词:Myocardial fibrosis pathogenesis ventricular remodeling anti-heart failure drugs |
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| 中文摘要: |
| 心肌纤维化是由多种病理因素参与导致心脏疾病发展到一定阶段所具有的共同病理改变,是心室重构的主要原因,与多种心血管疾病密切相关。心衰作为各种心脏疾病的严重表现和晚期阶段,已有不同程度的心室重构。本文从肾素-血管紧张素-醛固酮系统、细胞因子、血管内皮活性物质等方面阐述心肌纤维化的可能发病机制,并基于目前国内外文献已经报道的抗心衰药物,从抑制心肌纤维化以延缓和逆转心室重构方面进行综述。 |
| 英文摘要: |
| Myocardial fibrosis is a common pathological change caused by a variety of pathological factors leading to the development of heart disease to a certain stage. It is the main cause of ventricular remodeling and is closely related to a variety of cardiovascular diseases.Heart failure as a serious manifestation and late stage of various heart diseases and has different degrees of ventricular remodeling.In this paper, the possible pathogenesis of myocardial fibrosis is described from the aspects of renin-angiotensin-aldosterone system, cytokines, vascular endothelial active substances, etc., and based on the existing domestic and foreign literatures of anti-heart failure drugs, the aspects of inhibiting myocardial fibrosis to delay and reverse ventricular remodeling are reviewed. |
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