| 何诗雅,余楷,王新昌.基于文献数据挖掘中药复方治疗皮肌炎的用药规律[J].浙江中西医结合杂志,2022,32(2): |
| 基于文献数据挖掘中药复方治疗皮肌炎的用药规律 |
| Study on The Medication Rules of The Prescription for Dermatomyositis Based on Literature Data Mining |
| 投稿时间：2021-08-08 修订日期：2021-08-18 |
| DOI： |
| 中文关键词: 数据挖掘 皮肌炎 中药复方 用药规律 |
| 英文关键词:Data mining Dermatomyositis The prescription Medication rules |
| 基金项目: |
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| 摘要点击次数: 697 |
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| 中文摘要: |
| 目的 运用文献数据挖掘的方式,探究中医复方治疗皮肌炎的用药规律。方法 收集多个数据库建库至今中医文献中治疗皮肌炎的中药复方,提取方药信息,运用频数分析、关联规则分析、系统聚类分析等方法进行数据挖掘,探究其内在的中医用药规律。结果 筛选出99篇文献,共125张中医处方,涉及268味药,其中使用频次≥20次的中药有20味,使用最频繁的前六味为黄芪、茯苓、生地黄、牡丹皮、赤芍、白术。药物类别共19类,主要为清热药、补虚药、祛风湿药、活血祛瘀药、解表药、利水渗湿药等。药性寒性最多,其次为温、平性药物；药味以苦、甘、辛味最为多见；归经多入肝、肺、胃、脾等经。关联规则分析显示常用药物组合主要有赤芍、牡丹皮→生地黄,党参→黄芪,白术、茯苓→黄芪,牡丹皮、黄芪→生地黄,玄参→生地黄,白术→黄芪等。高频药物系统聚类分析得到个4聚类方,主要体现出中医治疗皮肌炎多采用补气健脾,清热凉血,祛风除湿,活血化瘀等治法。结论 皮肌炎有“虚、风、热、湿、瘀”的特点,病机总属本虚标实。从卫气营血辨证来看,皮肌炎辨证用药直达营分和血分；从脏腑辨证来看,皮肌炎辨证用药多在于肝、肺、胃、脾脏腑,注重气血的疏理和调养,有“治痿者独取阳明”的特色。故治疗上在补气健脾的同时,也须兼顾清热凉血、祛风除湿、活血化瘀。 |
| 英文摘要: |
| Objective: Use the method of literature data mining to explore the medication rules of the prescription for dermatomyositis. Methods: Collect the prescriptions of dermatomyositis in the traditional Chinese medicine literature since the establishment of multiple databases, extract the prescription information, use frequency analysis, association rule analysis, system clustering analysis and other methods for data mining to explore the inherent rules of traditional Chinese medicine. Results: A total of 125 prescriptions of 99 literatures were selected, involving 268 herbs. Among which 20 herbs were used more than 20 times. And the top six most frequently used herbs were Huangqi, Fuling, Shengdi, Mudanpi, Chishao, Baizhu. There are 19 categories of herbs, including heat clearing herbs, deficiency tonic herbs, wind-damp-dispelling herbs, blood-activating herbs for removing blood stasis, diaphoretic recipes, water-enhancing herbs for dampness and so on. Cold properties were the most, followed by warm and flat herbs. The most common medicinal tastes were bitter, sweet and spicy. Most of these herbs are directed to the liver, lung, stomach and spleen. Association rule analysis showed that the common herb combinations mainly included Chishao、Mudanpi→Shengdihuang,Dangshen→Huangqi,Baizhu、Fuling→Hangqi,Mudanpi、Huangqi→Shengdihuang,Xuanshen→Shengdihuang,Baizhu→Huangqi and so on. High-frequency herb system cluster analysis has obtained four cluster formulae, which mainly reflects the TCM treatment of dermatomyositis mainly adopts the therapeutic methods such as tonifying qi and invigorating spleen, clearing heat and cooling blood, eliminating wind and dehumidifying, promoting blood circulation and removing stasis. Conclusion: Dermatomyositis has the characteristics of "deficiency, wind, heat, dampness and blood stasis". From the point of view of syndrome differentiation of wei Qi ying and blood, dermatomyositis syndrome differentiation drugs directly to camp and blood division; From the perspective of syndrome differentiation of zang-fu organs, dermatomyositis syndrome differentiation drugs mainly focus on liver, lung, stomach, spleen zang-fu organs, pay attention to the regulating and recuperating of qi and blood, with the characteristics of "treating impotent alone take Yang Ming". Therefore, while supplementing qi and invigorating spleen, it is also necessary to clear heat and cool blood, dispel wind and dehumidify, promote blood circulation and remove stasis. |
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