| 王洁,洪书迟,赵昕峰,吴亦栋.CRP、PCT、PA及IL-6联合检测在患儿呼吸道感染诊断及预后中的价值研究[J].浙江中西医结合杂志,2022,32(7): |
| CRP、PCT、PA及IL-6联合检测在患儿呼吸道感染诊断及预后中的价值研究 |
| Study on the value of CRP，PCT，PA and IL-6 in diagnosis and prognosis in children with acute respiratory tract infection |
| 投稿时间：2021-08-31 修订日期：2022-05-20 |
| DOI： |
| 中文关键词: 急性呼吸道感染，C反应蛋白,白细胞介素-6,IL-6/PA |
| 英文关键词:acute respiratory tract infection PCT CRP IL-6 IL-6/PA |
| 基金项目: |
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| 中文摘要: |
| 目的 监测C反应蛋白（CRP）、降钙素原（PCT）、前白蛋白（PA）和白细胞介素-6（IL-6），计算C反应蛋白与前白蛋白比值(CRP/PA)、白细胞介素-6与前白蛋白比值(IL-6/PA),评估其对小儿呼吸道感染诊断及评估疗效的价值。方法 分析2020年1月-2020年6月在杭州市儿童医院接受住院治疗的150例呼吸道感染患儿临床资料，根据患儿病原感染类型的不同分为细菌感染组（n = 90）和非细菌感染组（n = 60），分别检测其入院时和治疗后CRP、PCT、PA及IL-6检测水平,并选取正常体检儿童55名作为对照组，比较感染组与对照组、细菌感染组与非细菌感染组CRP、PCT 、PA、IL-6、CRP/PA、IL-6/PA水平差异；比较细菌感染组治疗前和治疗后CRP、PCT 、PA、IL-6、CRP/PA、IL-6/PA水平差异；用受试者工作特征（ROC）曲线分析诊断效能。结果 感染组患儿CRP、PCT、IL-6、CRP/PA、IL-6/PA水平均高于对照组,PA水平低于对照组,差异有统计学意义（P <0. 05）,细菌感染组CRP、PCT、IL-6、CRP/PA、IL-6/PA水平高于非细菌感染组,差异有统计学意义（P <0.05）。治疗后, 细菌感染组患儿CRP、PCT、IL-6、CRP/PA、IL-6/PA水平较治疗前明显下降,PA水平明显升高,差异均有统计学意义（P< 0.05）。ROC曲线显示，IL-6/PA曲线下面积最大，为0.963，其诊断灵敏度为86.7%，特异度为90.9%。结论 CRP、PCT、PA、IL-6联合检测可作为诊断小儿急性呼吸道感染的有效指标,IL-6/PA有助于提高诊断效能，可以为早期鉴别感染类型、指导临床治疗和评估疗效提供参考依据。 |
| 英文摘要: |
| Objective:Monitoring the levels of c-reactive protein (CRP), procalciton (PCT),prealbumin(PA),interleukin-6(IL-6), calculate the ratio of CRP to PA and the ratio of IL-6 to PA to assess the value of which in diagnosis of acute respiratory tract infection.Methods:120 patients who are admitted with respiratory tract infection in Hangzhou Children’s Hospital from Jan 2020 to Jun 2020 were divided into two groups,one was bacterial infection with 90 patients and the other was non-bacterial infection with 60,which both considered to be experimental group.Besides there are 55 children who have a physical examination in our hospital regarding as the control group.Monitorring the change of CRP,PCT,PA ,IL-6,CRP/PA and IL-6/PA in serum,and the levels of CRP,PCT,PA ,IL-6,CRP/PA and IL-6/PA were measured before and after treatment in the bacterial infection group. Diagnostic value was measured by using receiver operating characteristic(ROC)curve.Results:The levels of CRP,PCT,IL-6,CRP/PA and IL-6/PA in the infection group were significantly higher than the control group and PA level was significantly lower than the control group(P < 0.05).The levels of CRP,PCT,IL-6,CRP/PA and IL-6/PA in the bacterial infection group were significantly higher than those in the non-bacterial infection group (P < 0.05).After treatment with anti-infective therapy,CRP,PCT,IL-6,CRP/PA and IL-6/PA were significantly lower than those before treatment and PA level was significantly higher than before (P < 0.05). ROC curve of IL-6/PA was the largest(0.963)，the sensitivity was 86.7%and the specificity was 96.0%．Conclusion:The detection of CRP,PCT, PA and IL-6 has certain value in identifying and diagnosing early childhood acute respiratory infection,Combined IL-6/PA testing can improve diagnostic efficiency,and it can guide clinical treatment and provide reference for prognosis. |
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