| 彭玉琳,余彩娥,金瑛,汪雯,周江文.调神益肾法针刺联合盐酸多奈哌齐治疗非痴呆性血管性认知障碍肾精亏虚证75例[J].浙江中西医结合杂志,2022,32(6): |
| 调神益肾法针刺联合盐酸多奈哌齐治疗非痴呆性血管性认知障碍肾精亏虚证75例 |
| Treatment of 75 cases of kidney essence deficiency syndrome with non-demented vascular cognitive impairment by Tiao-Shen-Yi-Shen acupuncture combined with Donepezil hydrochloride |
| 投稿时间：2021-10-08 修订日期：2022-05-06 |
| DOI： |
| 中文关键词: 调神益肾 非痴呆性血管性认知障碍 肾精亏虚证 针刺 盐酸多奈哌齐 |
| 英文关键词:Tiao-Shen-Yi-Shen Vascular cognitive impairment without dementia Deficiency of kidney essence Acupuncture Donepezil hydrochloride |
| 基金项目:浙江省中医药科技项目 |
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| 中文摘要: |
| 目的：分析调神益肾法针刺联合盐酸多奈哌齐片对非痴呆性血管性认知障碍(Vascular Cognitive Impairment N0,VCIND)肾精亏虚证患者的临床疗效，及血清同型半胱氨酸(Homocysteine,Hcy)水平的变化。方法：将纳入的160例VCIND患者随机分为观察组和对照组，各80例，均予调节血压、血糖、血脂、抗血小板聚集等基础治疗，对照组口服盐酸多奈哌齐片5mg/晚，6周后改为10mg/晚；观察组予基础治疗，口服盐酸多奈哌齐片5mg/晚，联合调神益肾法针刺治疗3次/周，疗程均为12周。治疗前后观察患者ADL、MoCA、中医证候积分、血Hcy及安全性情况。结果：观察组脱落5例，有效率为88%，对照组脱落3例，有效率为74%，有效率差异具有统计学意义（P＜0.05）。治疗后两组患者ADL、MoCA评分较治疗前均有升高，中医证候积分、血Hcy水平较治疗前均有降低（P＜0.05），治疗后，上述指标变化观察组较对照组更显著（P＜0.05）。结论：调神益肾法针刺联合盐酸多奈哌齐片在改善VCIND患者认知、日常生活自理能力和中医证候方面具有优势，具有较好的疗效，安全性较高。 |
| 英文摘要: |
| Objective: To analyze the clinical effect of Tiao-Shen-Yi-Shen acupuncture combined with Donepezil hydrochloride on non-dementia Vascular Cognitive Impairment N0 (VCIND) and the changes of serum Homocysteine (Hcy) level. Methods: 160 VCIND patients were randomly divided into observation group and control group, 80 patients in each group, all of whom were given basic therapy such as anti-platelet aggregation and regulation of blood pressure, blood glucose and blood lipids. The control group was given donepezil hydrochloride tablets 5mg/ night once, which was changed to 10mg/ night 6 weeks later. Observation group was given basic treatment, oral donepezil hydrochloride tablets 5mg/ night and Tiao-Shen-Yi-Shen acupuncture three times a week. The course of treatment is 12 weeks. ADL, MoCA, TCM syndrome score, blood Hcy and safety were observed before and after treatment. Results: The observation group shed 5 cases, the effective rate was 88%, the control group shed 3 cases, the effective rate was 74%, the difference was statistically significant (P < 0.05). After treatment, ADL and MoCA scores in 2 groups were increased compared with before treatment, TCM syndrome score and blood Hcy level were decreased compared with before treatment (P < 0.05). After treatment, changes of above indicators in observation group were more significant than control group (P < 0.05). Conclusion: Tiao-Shen-Yi-Shen acupuncture combined with Donepezil hydrochloride tablets has advantages in improving VCIND patients' cognition, self-care ability in daily life and TCM syndrome, with good efficacy and high safety. |
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