| 叶如剑,陈忠武,沈丽娟,王一.宽胸气雾剂治疗冠心病心绞痛的疗效及对患者冠脉微循环阻力指数的影响[J].浙江中西医结合杂志,2022,32(7): |
| 宽胸气雾剂治疗冠心病心绞痛的疗效及对患者冠脉微循环阻力指数的影响 |
| Effect of Kuanxiong aerosol on angina pectoris and its influence on coronary microcirculation resistance index |
| 投稿时间：2021-10-12 修订日期：2022-01-26 |
| DOI： |
| 中文关键词: 冠心病 心绞痛 冠状动脉微循环阻力指数 宽胸气雾剂 |
| 英文关键词:Coronary Heart Disease Angina Pectoris Coronary Index of Microcirculation Resistance Kuanxiong Aeroso |
| 基金项目:玉环市科技计划项目,202026 |
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| 中文摘要: |
| [摘要]目的 探讨宽胸气雾剂治疗冠心病心绞痛（UA）的疗效及对患者冠脉微循环阻力指数的影响。方法 研究选择的研究对象是在我院就诊的174例UA患者，研究开展时间为2018年6月至2020年5月，将所有患者随机分为对照组（87例）和观察组（87例）。对照组给予常规处理，观察组在对照组基础上给予宽胸气雾剂治疗。观察2组患者治疗前后心绞痛发作次数、硝酸甘油用量、中医证候积分、IMR、血流变参数，统计2组患者临床疗效和治疗期间的不良反应。结果 治疗后2组患者IMR、心绞痛发作次数、硝酸甘油用量、中医证候积分、全血高切黏度、全血低切黏度、血浆黏度、红细胞聚集指数较治疗前显著降低（P＜0.05），且观察组与对照组上述指标相比较显著降低（P＜0.05）。观察组临床有效率高于对照组（P＜0.05）。2组患者不良反应发生率相比较差异均无统计学意义（P＞0.05）。结论 宽胸气雾剂治疗UA可改善临床症状，提高临床疗效，安全性良好，改善血流变障碍进而降低IMR可能是其发挥作用的重要机制。 |
| 英文摘要: |
| [Abstract] Objective To investigate the effect of Kuanxiong aerosol on unstable angina pectoris (UA) and its influence on coronary IMR. Methods 174 patients with UA in our hospital from June 2018 to may 2020 were selected as the research objects, and were randomly divided into control group and observation group with 87 cases in each group. The control group was given conventional treatment, and the observation group was treated with Kuanxiong aerosol on the basis of the control group. Angina pectoris attack times, nitroglycerin dosage, TCM syndrome score, IMR and hemorheology parameters were observed before and after treatment in the two groups, and the clinical efficacy and adverse reactions during treatment were counted. Results After treatment, IMR, frequency of angina pectoris attack, dosage of nitroglycerin, TCM syndrome score, whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and erythrocyte aggregation index were significantly lower than those before treatment (P < 0.05), and the above indexes in the observation group were significantly lower than those in the control group (P < 0.05).The clinical effective rate of the observation group was higher than that of the control group (P < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05).Conclusion Kuanxiong aerosol in the treatment of UA can improve the clinical symptoms, improve the clinical efficacy, with good safety, improve hemorheological disorders and reduce IMR, which may be an important mechanism of its role. |
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