| 陈佳园,陈怡,陈成帷,张益光,余炳取,林芊如,贾杰.溃疡性结肠炎患者C反应蛋白/白蛋白比值与疾病活动性的相关性研究[J].浙江中西医结合杂志,2022,32(11): |
| 溃疡性结肠炎患者C反应蛋白/白蛋白比值与疾病活动性的相关性研究 |
| The relationship between C-Reactive protein/albumin ratio and disease activity in patients with ulcerative colitis |
| 投稿时间：2021-10-12 修订日期：2022-05-14 |
| DOI： |
| 中文关键词: 溃疡性结肠炎 疾病活动性 敏感性 特异性 |
| 英文关键词:Ulcerative colitis Disease activity Sensitivity Specificity |
| 基金项目:浙江省医药卫生科技计划项目（2017KY629） |
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| 中文摘要: |
| 目的 探讨C反应蛋白/白蛋白比值(CRP/ALB)、炎症标志物和全血计数(CBC)水平与溃疡性结肠炎(UC)活动性的相关性。方法 将2015年1月至2020年12月本院诊治的183例溃疡性结肠炎(UC)患者纳入研究，分析血清C-反应蛋白(CRP)、白蛋白(ALB)、血沉(ESR)和CBC与UC活动性的关系。采用Mayo评分评估UC患者的疾病活动性。结果 活动期UC患者CRP/ALB比值、CRP、ESR、血小板/淋巴细胞比率(PLR)、红细胞分布宽度(RDW)、中性粒细胞/淋巴细胞比率(NLR)明显高于稳定期，而ALB和淋巴细胞/单核细胞比率(LMR)明显低于稳定期(P<0.001)。CRP/ALB比值同不同程度分级UC活动性均存在强关联（r>0.6, P<0.001）。ROC曲线分析结果显示，活动期UC的CRP/ALB比值的最佳截断值为0.17，敏感性为67.9%，特异性为86.5%，Youden指数0.544。多因素Logistic回归分析显示，在调整炎症标志物(ESR、NLR、PLR和LMR)后，CRP/ALB比值在区分UC疾病活动性上具有统计学意义。结论 CRP/ALB比值水平与UC疾病活动性密切相关，存在正向强关联，可用于UC疾病活动性的评估。 |
| 英文摘要: |
| Objective To evaluate the C-reactive protein/albumin ratio (CRP/ALB), inflammatory markers and complete blood count (CBC) parameters in patients with ulcerative colitis (UC) and their relationship with disease activity. Methods A retrospective analysis of 183 cases of ulcerative colitis (UC) with serum C-reactive protein (CRP), albumin (ALB), erythrocyte sedimentation rate (ESR) and CBC parameters was taken during January 2015 to December 2020. The Mayo score was used to evaluate the disease activity of UC patients. The relationship between the above parameters and disease activity was discussed. Results The CRP/ALB ratio, CRP, ESR, platelet/lymphocyte ratio (PLR), red blood cell distribution width (RDW), neutrophil/lymphocyte ratio (NLR) of patients with active UC were significantly higher than those of patients with stable UC, while ALB and lymphocyte/monocyte ratio (LMR) were significantly lower than that of patients with stable UC (P<0.001).The CRP/ALB ratio was strongly correlated with different levels of UC activity (r>0.6, P<0.001).ROC curve analysis results showed that the best cut-off value of CRP/ALB ratio for active UC was 0.17, the sensitivity was 67.9%, the specificity was 86.5% and the Youden index was 0.544. Multivariate logistic regression analysis showed that after adjusting these inflammatory markers (ESR, NLR, PLR, and LMR), the CRP/ALB ratio was a significant parameter to distinguish the disease activity of UC. Conclusion The CRP/ALB ratio level is closely related to UC disease activity, and there is a strong positive correlation, which can be used to evaluate UC disease activity. |
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