| 於李龙,陈文华,秦路平,朱波.中药与肠道菌群相互作用的研究进展[J].浙江中西医结合杂志,2022,32(9): |
| 中药与肠道菌群相互作用的研究进展 |
| Research progress on cross talk of traditional Chinese medicine with intestinal flora |
| 投稿时间：2021-12-25 修订日期：2022-02-10 |
| DOI： |
| 中文关键词: 中药 肠道菌群 相互作用 粪菌移植 内生菌 |
| 英文关键词:Traditional Chinese medicine Intestinal flora Cross talk Fecal microbiota transplantation endophyte |
| 基金项目: |
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| 中文摘要: |
| 近年来,中药与肠道菌群的相互作用一直是中药药理学与药代动力学的研究热点。大量研究表明,中药口服后会与肠道菌群发生相互作用：一方面,中药(药用植物)的活性成分和内生菌可调节肠道菌群的群落组成和相对丰度达到治疗疾病的效果；另一方面,肠道菌群对中药的活性成分进行转化与修饰,使得中药代谢产物表现出不同的生物利用度、药理及毒性活性。粪菌移植是验证中药调节肠道菌群的重要手段之一。本文综述了中药与肠道菌群之间的相互作用,并探讨了其互作的中药活性成分与效应机制,以期为中药新药开发及作用机制研究提供参考。 |
| 英文摘要: |
| Interaction between Traditional Chinese medicine (TCM) and intestinal flora has raised public attention, especially in the area of pharmacology and pharmacokinetics. Many studies demonstrated that oral TCM could cross talk with intestinal flora. Active ingredients and endophytes ofTCM could regulate the composition and abundance of intestinal flora to treat disease. Meanwhile, intestinal flora could bio-transform and modify the active ingredients of TCM, causing different bio-availability, pharmacological effects and toxicity of TCM metabolites. In addition, fecal bacteria transplantation is one of the essential methods to verify the regulation effect of TCM on intestinal flora. Thus, we summarized the interaction of TCM with intestinal flora, and discussed the bio-active ingredients and mechanism of the interaction. The aim of this review is to provide a reference on discovery of new drugs and the action mechanism of TCM. |
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