| 罗妍,陈丽花,钱新月,顾晓霞,万江平,张东凯,王宙政,韩艳霞,胡蓓莉.预后营养指数PNI与营养风险筛查评分NRS2002 在弥漫大B细胞淋巴瘤中的预后意义[J].浙江中西医结合杂志,2022,32(12): |
| 预后营养指数PNI与营养风险筛查评分NRS2002 在弥漫大B细胞淋巴瘤中的预后意义 |
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| 投稿时间：2022-03-06 修订日期：2022-09-15 |
| DOI： |
| 中文关键词: 弥漫大B细胞淋巴瘤 预后营养指数 营养风险筛查评分 预后 |
| 英文关键词:diffuse large B-cell lymphoma, prognostic nutritional index, nutritional risk screening score, prognosis |
| 基金项目:B细胞淋巴瘤组织中TRIP13表达与染色体异常及Ki-67指数的相关性研究,基金号:2018AD32033 |
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| 中文摘要: |
| 目的：探讨预后营养指数PNI与营养风险筛查评分NRS2002在弥漫大B细胞淋巴瘤中的临床及预后意义。方法：回顾性分析2010年1月1日至2019年12月31日嘉兴市第二医院初诊的85例弥漫大B细胞淋巴瘤患者和同期本院健康体检中心24615例体检者(健康对照组)的临床资料，比较两组人群 PNI 的差异。通过受试者工作特征 (receiver operating characteristic，ROC)曲线确定PNI分界值，分为高PNI组(≥43.05)和低PNI组(<43.05)，评价两组患者临床病理特征之间的相关性，以及两组间的总生存的情况。同时把85例患者根据NRS2002评分分为高NRS2002组（≥3）和低NRS2002组（＜3），比较两组间的临床特征和总生存。结果：高PNI组和低PNI组相比，在乳酸脱氢酶水平（246.11±123.31 VS 390.42±293.25，P=0.007）、β2微球蛋白水平（1.91±1.08 VS 3.36±2.65，P=0.003）、白蛋白水平（40.77±5.06 VS 32.90±4.00，P=0.000）、白细胞水平（7.02±5.06 VS 4.79±2.12，P=0.016）、血红蛋白水平（125.28±19.28 VS 109.63±23.04，P=0.001）均有显著性差异，淋巴瘤分期、危险分层、有无骨髓侵犯方面也有统计学差异（P值均＜0.05）；低NRS2002组和高NRS2002组相比，在β2微球蛋白水平（2.06±1.06 VS 2.93±2.54，P=0.039）、血小板水平（207.65±71.83 VS 172.89±64.40，P=0.021）有显著性差异，在危险分层、有无B症状也有显著性差异（P值均＜0.05）。高PNI组总生存优于低PNI组（P=0.026），低NRS2002组总生存优于高NRS2002组之（P=0.032）。结论：高PNI组及低NRS2002组具有更好的一些临床特征，且高PNI组和低NRS2002组具有更好的预后。 |
| 英文摘要: |
| object：To explore the clinical and prognostic significance of the prognostic nutritional index PNI and nutritional risk screening score NRS2002 in diffuse large B-cell lymphoma. Method：A retrospective analysis of the clinical data of 85 patients with diffuse large B-cell lymphoma who were newly diagnosed in Jiaxing Second Hospital from January 1, 2010 to December 31, 2019, and 24615 patients (healthy control group) in the health examination center of the hospital during the same period Data, compare the differences in PNI between the two groups. The PNI cut-off value was determined by the receiver operating characteristic (ROC) curve, and divided into high PNI group (≥43.05) and low PNI group (<43.05), to evaluate the correlation between the clinicopathological characteristics of the two groups of patients, And the overall survival between the two groups. At the same time, 85 patients were divided into high NRS2002 group (≥3) and low NRS2002 group (<3) according to the NRS2002 score, and the clinical characteristics and overall survival between the two groups were also compared. Result：Compared with the low PNI group, the levels of lactate dehydrogenase (246.11±123.31 VS 390.42±293.25, P=0.007), β2 microglobulin level (1.91±1.08 VS 3.36±2.65, P=0.003), white Protein level (40.77±5.06 VS 32.90±4.00, P=0.000), white blood cell level (7.02±5.06 VS 4.79±2.12, P=0.016), hemoglobin level (125.28±19.28 VS 109.63±23.04, P=0.001) were all significant. There are also statistical differences in lymphoma staging, risk stratification, and presence or absence of bone marrow invasion (all P values <0.05). Compared with the high NRS2002 group and the low high NRS2002 group, the β2 microglobulin level (2.06±1.06 VS 2.93±2.54, P=0.039), platelet level (207.65±71.83 VS 172.89±64.40, P=0.021) were all significant differences, and there were also significant differences in risk stratification, with or without B symptoms (all P<0.05). The overall survival of high PNI group was longer than that in the low PNI group.(P=0.026). And longer overall survival was observed in the low NRS2002 group than the high NRS2002 group(P=0.032). Conclusion：The high PNI group and the low NRS2002 group have more better clinical characteristics. And the high PNI group and the low NRS2002 group have a better overall survival. |
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