| 孙天智,汝触会,陈爱凤,张文智,何飞.保肺定喘颗粒治疗慢性阻塞性肺疾病合并肺动脉高压气虚痰瘀型患者临床观察[J].浙江中西医结合杂志,2022,32(12): |
| 保肺定喘颗粒治疗慢性阻塞性肺疾病合并肺动脉高压气虚痰瘀型患者临床观察 |
| Clinical Observation of Baofei Dingchuan Granules Treatment on Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Arterial Hypertension Patients with Qi Deficiency and phlegm stasis type |
| 投稿时间：2022-03-26 修订日期：2022-10-31 |
| DOI： |
| 中文关键词: 慢性阻塞性肺疾病 肺动脉高压 益气活血通络法 气虚痰瘀型 |
| 英文关键词:chronic obstructive pulmonary disease pulmonary arterial hypertension tonifying qi, promoting blood flow and dredging collaterals method qi deficiency and phlegm stasis type |
| 基金项目:杭州市科技发展计划(20191203B126)； |
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| 中文摘要: |
| 目的：观察益气活血通络法对慢性阻塞性肺疾病合并肺动脉高压(COPD-PH)气虚痰瘀型患者的临床症候、肺动脉压力及肺血管形态学的影响。方法：将65例COPD合并PH患者随机分为观察组(33例)和对照组(32例),对照组根据指南采用吸氧和吸入制剂等西医治疗,观察组在对照组基础上口服中药保肺定喘颗粒,治疗3月后,评价两组患者临床症候、肺动脉压力及肺血管形态学变化。结果：①治疗后两组患者临床症候积分、肺动脉压力比较具有统计学意义(P均小于0.05)；②治疗后肺血管形态学各指标组间比较无统计学差异(P均>0.05)。结论：运用益气活血通络法治疗可以改善COPD-PH患者气虚痰瘀型患者临床症候、降低肺动脉压力,但无法改善肺血管形态,考虑与肺血管重构可逆性较差有关。 |
| 英文摘要: |
| Objective: To observe the effect of tonifying qi, promoting blood flow and dredging collaterals treatment on clinical symptoms, pulmonary artery pressure and pulmonary vascular morphology in patients with chronic obstructive pulmonary disease complicated with pulmonary hypertension (COPD-PH) with qi deficiency and phlegm stasis.Methods: Totally 65 COPD-PH patients with qi deficiency and phlegm stasis were randomly divided into observation group of 33 cases and control group of 32 cases. The control group was treated with western medicine such as oxygen inhalation and inhalation preparations according to the guidelines, and the observation group was given the traditional Chinese medicine Baofei Dingchuan Granules on the basis of the control group. After 3 months of treatment, the clinical symptoms, pulmonary artery pressure and pulmonary vascular morphological changes were evaluated in the two groups of patients.Results: ①After treatment, the clinical symptom scores and pulmonary arterial pressure of the two groups were statistically significant (P<0.05); ②There was no statistical difference in the morphological indexes of pulmonary blood vessels between the two groups after treatment (P>0.05). Conclusion:. Tonifying qi, promoting blood flow and dredging collaterals method for COPD-PH with qi deficiency and blood stasis could improve the patient’s clinical symptoms and reduce pulmonary artery pressure, but cannot improve the pulmonary vascular morphology, which is considered to be related to the irreversible pulmonary vascular remodeling. |
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