| 张青,杨洞洞.柴贝止痫颗粒添加治疗对痰气郁滞型颞叶癫痫共患病的影响[J].浙江中西医结合杂志,2022,32(10): |
| 柴贝止痫颗粒添加治疗对痰气郁滞型颞叶癫痫共患病的影响 |
| Effect of Chaibei Zhixian Granule on Comorbidity of Temporal Lobe Epilepsy with Phlegm-qi Constraint and Stagnation |
| 投稿时间：2022-04-02 修订日期：2022-08-24 |
| DOI： |
| 中文关键词: 颞叶癫痫 柴贝止痫颗粒 共患病 焦虑 抑郁 睡眠障碍 |
| 英文关键词:Temporal Lobe Epilepsy Chaibei Zhixian Gragule Comorbidity Anxiety Depression Sleep disorders |
| 基金项目:浙江省自然科学基金一般项目(LY18H270010),浙江省中医药科技计划科研(2017ZKL009) |
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| 中文摘要: |
| 目的 观察柴贝止痫颗粒添加治疗对痰气郁滞型颞叶癫痫(TLE)患者癫痫发作、情绪、睡眠的影响,为临床治疗TLE及共患病提供思路。方法 收集2017年1月1日至2020年6月30日在浙江中医药大学附属第一医院就诊的辨证分型符合痰气郁滞型的TLE患者70例,随机分为治疗组、对照组,对照组予常规抗发作西药治疗,治疗组在常规抗发作西药治疗的基础上添加柴贝止痫颗粒。两组分别治疗12周，观察治疗前后两组癫痫发作频率、癫痫抑郁量表(NDDI-E)、广泛性焦虑障碍量表(GAD-7)、阿森斯失眠量表(AIS)、爱泼沃斯思睡量表(ESS)评分的变化。比较两组50%应答率（response rates，RR）、完全缓解率及癫痫共患病发生率。结果 治疗后，治疗组与对照组发作频次均较治疗前降低（P<0.01），且治疗组低于对照组（P<0.05）；治疗组50%RR高于对照组（P<0.05）。治疗后，治疗组焦虑障碍的发生率低于对照组（P<0.05），两组NDDI-E、GAD-7评分均较治疗前降低（P<0.01），且治疗组GAD-7评分低于对照组（P<0.05）。治疗后，治疗组共患失眠的比例低于对照组（P<0.05），两组AIS、ESS评分均较治疗前降低（P<0.01），且治疗组低于对照组（P<0.05，P<0.01）。结论 柴贝止痫颗粒添加治疗在降低痰气郁滞型TLE患者发作频率的同时,可稳定患者情绪、改善睡眠。 |
| 英文摘要: |
| Objective To observe the effects of Chaibei Zhixian Granule (CZG) on the frequency of seizure, mood and sleep in patients with Phlegm-qi Constraint and Stagnation (PQCS) pattern of temporal lobe epilepsy (TLE), so as to provide ideas for clinical treatment of TLE and comorbidity in TLE. Methods The clinical information of 70 TLE patients with PQCS pattern in the First Affiliated Hospital of Zhejiang Chinese Medical University from January 1, 2017 to June 30, 2020 were collected and randomly divided into treatment group and control group. The control group was given routine treatment of anti-seizure medications (ASMs), and CZG was administered in the treatment group on the basis of ASMs for 12 weeks. The frequency of seizures, and the scores of Neurological disorders depression inventory for epilepsy (NDDI-E), Generalized Anxiety Disorder(GAD-7), Athens Insomnia Scale(AIS) and Epworth Sleepiness Scale(ESS) were recorded. 50% response rates (RR), complete remission rate and incidence of epilepsy comorbidity were compared between the two groups. Results: The frequencies of seizures were decreased in the two groups after treatment (P < 0.01), and the frequency of the treatment group was lower than that of the control group (P < 0.05); 50% RR in the treatment group was higher than that in the control group (P < 0.05). After treatment, the incidence of anxiety disorder in the treatment group was lower than that in the control group (P < 0.05), the scores of NDDI-E and GAD-7 in the two groups were lower than those before treatment (P < 0.01), and the score of GAD-7 in the treatment group was lower than that in the control group (P < 0.05). After treatment, the proportion of insomnia in the treatment group was lower than that in the control group (P < 0.05), the scores of AIS and ESS in the two groups were lower than those before treatment (P < 0.01), and the treatment group was lower than that in the control group (P < 0.05, P < 0.01). Conclusion: CZG can reduce the frequency of seizures and alleviate the mood and sleep disorders of TLE patients with PQCS pattern. |
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