| 柳锐凡,蒋合,高祥福.基于数据挖掘的高祥福治疗干燥综合征用药规律研究[J].浙江中西医结合杂志,2022,32(10): |
| 基于数据挖掘的高祥福治疗干燥综合征用药规律研究 |
| The Medication Rule of GAO Xiangfu in Treating Sjogren's syndrome Based on Data Mining |
| 投稿时间：2022-04-19 修订日期：2022-05-18 |
| DOI： |
| 中文关键词: 干燥综合征 用药规律 高祥福 数据挖掘 |
| 英文关键词:Sjogren's syndrome Medication rule GAO Xiangfu Data mining |
| 基金项目:2020年浙江省名老中医专家传承工作室建设项目(No.GZS2020027) |
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| 中文摘要: |
| 目的：通过数据挖掘总结高祥福教授治疗干燥综合征（Sjogren's syndrome, SS）的用药规律。方法：收集高祥福2019年9月至 2022年2月通过门诊治疗的干燥综合征患者病历数据，建立方药数据库，对数据进行规范化处理。采用Excel 2007、SPSS Modeler 18.0、SPSS Statistic 25.0等软件对药物及其性味归经等进行频数分析，对高频药物进行关联规则分析、聚类分析。结果：纳入有效处方432首，共涉及191味药，累及频次6621次。用药频次位于前5的分别是丹参、麦冬、生地黄、黄芩、黄芪，药性多寒、平，药味多甘、苦、辛，多归肝、肺、脾、胃经，用药以补虚药、清热药、活血化瘀药、利水渗湿药最为多见。麦冬—茵陈、麦冬—石斛、生地黄—青蒿、麦冬—天冬等关联度较高，为常用药对。高频聚类得到6类药物组合。结论：高祥福教授辨治干燥综合征时，以气阴两虚为本，瘀热互结为标，治疗上强调补阴为基本大法，兼顾气阴双补、清热生津、养血活血之法。 |
| 英文摘要: |
| [Objective] To summarize the medication rule of Professor Gao Xiangfu in the treatment of Sjogren's syndrome by using data mining. [Methods] The medical records of patients with Sjogren's syndrome treated by Gao Xiangfu from September 2019 to February 2022 were collected, and the prescription database was established to conduct standardized processing of the data. Excel 2007, SPSS Modeler 18.0, SPSS Statistic 25.0 were used for frequency analysis of Chinese herbs and their nature and flavor, and systematic cluster analysis and association rule analysis were conducted on the high-frequency herbs. [Results] 432 effective prescriptions were included, involving 191 kinds of Chinese herbs in total and involving frequency 6621 times. The top 5 items were Salviae Miltiorrhiza (Danshen), Radix Ophiopogonis (Maidong), Rehmannia Glutinosa (Shengdihuang), Baikal Skullcap (Huangqin) and Astragalus Membranaceus (Huangqi). Cold, mild nature and sweet, bitter, spicy flavor were used frequently. Most of the herbs belong to liver, lung, spleen and stomach meridian. Deficiency-supplementing herbs, heat -clearing herbs, herbs for promoting blood circulation and removing blood stasis and diuresis-inducing and dampness-draining medicine were the most frequently used. The association degree of “Radix Ophiopogonis - Herba Artemisiae Scopariae”, “Radix ophiopogonis – Dendrobium”, “Rehmannia Glutinosa - Artemisia Annua”, “Radix Ophiopogonis – Asparagus” was high, which were commonly used pair-drugs. Six drug combinations were obtained by high frequency cluster analysis. [Conclusion] In the treatment of Sjogren's syndrome, Professor Gao Xiangfu took deficiency of Qi -Yin as the base, blood stasis and heat as the standard. He emphasized supplementing Yin as the basic method, giving consideration to replenish Qi - Yin, clearing heat and promoting fluid, nourishing blood and promoting blood circulation. |
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