| 徐卓涵,张培培,何灵芝.SGLT2抑制剂联合加味黄风汤治疗大量白蛋白尿糖尿病肾病患者临床效果观察[J].浙江中西医结合杂志,2023,33(5): |
| SGLT2抑制剂联合加味黄风汤治疗大量白蛋白尿糖尿病肾病患者临床效果观察 |
| Curative Effect Observation on SGLT-2 inhibitor Combined with Modified Huangfeng Tang for Diabetic Kidney Disease with severely increased albuminuria |
| 投稿时间：2022-04-24 修订日期：2023-02-22 |
| DOI： |
| 中文关键词: 糖尿病肾病 SGLT2抑制剂 加味黄风汤 UACR |
| 英文关键词:Diabetic Kidney Disease SGLT-2 inhibitor Modified Huangfeng Tang UACR |
| 基金项目:] 国家自然科学(81603572)；浙江省自然科学(LQ15H270002) |
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| 中文摘要: |
| 目的：观察钠-葡萄糖协同转运蛋白2（sodium-glucose cotransporter 2，SGLT2）抑制剂联合加味黄风汤对大量白蛋白尿糖尿病肾病患者的临床疗效。方法：选择医院2020年12月至2022年12月诊治的伴有大量白蛋白尿的风湿内扰型糖尿病肾病患者60例，根据治疗方案不同分为观察组（n=30）和对照组（n=30）。观察组患者接受SGLT2抑制剂联合加味黄风汤治疗，对照组患者接受SGLT2抑制剂治疗。两组患者均治疗12周，后比较两组患者临床疗效和尿微量白蛋白/肌酐比值（Urinary albumin/creatinine ratio，UACR）变化。结果：治疗组与对照组总有效率分别为 76.66%、53.33%，2组比较，差异有统计学意义（P＜0.05）。治疗前两组UACR无统计学差异（P>0.05）。各组治疗前后组内比较，UACR水平较治疗前下降，UACR差异比较有统计学意义（P＜0.05），而且观察组患者治疗后UACR水平低于对照组（P＜0.05）。结论：SGLT2抑制剂联合加味黄风汤治疗大量白蛋白尿糖尿病肾病能降低白蛋白尿，明显提升疗效。 |
| 英文摘要: |
| Objective To observe the clinical effect of Sodium-glucose co-transporter (SGLT)-2 inhibitor combined with Modified Huangfeng Tang on diabetic kidney disease(DKD)with severely increased albuminuria. Methods A total of 60 DKD patients with severely increased albuminuria of wind-damp harassing the interior type diagnosed and treated in our hospital between December 2020 to December 2022 were enrolled and divided into the observation group (n=30) and the control group (n=30) by different treatments. Patients in the observation group were treated with SGLT-2 inhibitor combined with Modified Huangfeng Tang, while patients in the control group were treated with SGLT-2 inhibitor. After twelve weeks of treatment，The two groups were compared for the clinical efficacy and Urinary albumin/creatinine ratio (UACR). Results The total effective rate in the observation group and the control group was 76.66% and 53.33% respectively，the difference being significant (P<0.05). Before treatment， there was no significant difference being found in the comparison of UACR (P>0.05). After treatment, there was a reduction in UACR in the either group. Within-group comparison showed that there was a difference in UACR between baseline and after treatment (P＜0.05)， and the reduction was greater in the observation group (P＜0.05). Conclusion The therapy of SGLT-2 inhibitor Combined with Modified Huangfeng Tang for DKD with severely increased albuminuria can reduce the albuminuria of the patients and significantly improving the treatment effect. |
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