| 康斯丹,黄巧玲,王迅.三种非甾体抗炎药对伊曲康唑体外血浆蛋白结合率的影响[J].浙江中西医结合杂志,2023,33(4): |
| 三种非甾体抗炎药对伊曲康唑体外血浆蛋白结合率的影响 |
| Effects of three NSAIDs on the plasma protein binding rate of itraconazole in vitro |
| 投稿时间：2022-05-11 修订日期：2022-09-23 |
| DOI： |
| 中文关键词: 伊曲康唑 双氯芬酸钠 布洛芬 美洛昔康 血浆蛋白结合率 |
| 英文关键词:itraconazole diclofenac sodium ibuprofen meloxicam plasma protein binding rate |
| 基金项目:浙江中西医结合学会临床药学科研专项 |
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| 中文摘要: |
| 目的 研究双氯芬酸钠、布洛芬、美洛昔康三种非甾体抗炎药对伊曲康唑体外血浆蛋白结合率的影响。方法 建立血浆及透析外液中伊曲康唑浓度的HPLC法，采用平衡透析法，测定未加和加入双氯芬酸钠、布洛芬、美洛昔康三种非甾体抗炎药后伊曲康唑的血浆蛋白结合率。结果 伊曲康唑在1,0.5,0.2 mg?L-1三个浓度时，其体外血浆蛋白结合率分别为（96.49±0.32）%、（96.52±0.24）%、（96.21±0.18）%；对照组、双氯芬酸钠组、布洛芬组、美洛昔康组的高、中、低三个浓度结果均无显著差异（P >0.05），双氯芬酸钠组、布洛芬组与对照组比较显著降低（P < 0.05）；美洛昔康组与对照组比较无显著差异（P >0.05）；双氯芬酸钠组和布洛芬组比较无显著差异（P >0.05）。结论 双氯芬酸钠、布洛芬能降低伊曲康唑血浆蛋白结合率，在联合用药时应注意其药物相互作用。 |
| 英文摘要: |
| OBJECTIVE To study the effects of three NSAIDs, diclofenac sodium, ibuprofen, and meloxicam on the plasma protein binding rate of itraconazole.in vitro .METHODS The equilibrium dialysis combined with HPLC were employed to determine the plasma protein binding rate of itraconazole without and after the addition of diclofenac sodium, ibuprofen, and meloxicam.RESULTSUnder the concentration of 1，0.5，0.2 mg?L-1，the plasma protein binding rate of itraconazole was（96.49±0.32）%、（96.52±0.24）%、（96.21±0.18）%.There was no significant difference in the results of high, medium and low concentrations between the control group, diclofenac sodium group, ibuprofen group, and meloxicam group (P > 0.05). Compared with the control group, the diclofenac sodium group and ibuprofen group decreased significantly (P < 0.05); there was no significant difference between the meloxicam group and the control group (P > 0.05); there was no significant difference between the diclofenac sodium group and the ibuprofen group (P > 0.05). CONCLUSION Diclofenac sodium and ibuprofen can reduce the plasma protein binding rate of itraconazole,so we should pay attention to their drug interactions when combined. |
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