| 颜建飞,陈方红,卢伟业,戴丽雅,叶玲红,黄岩花.超声造影定量灌注参数对子宫内膜癌的预后价值[J].浙江中西医结合杂志,2023,33(7): |
| 超声造影定量灌注参数对子宫内膜癌的预后价值 |
| The value of quantitative perfusion parameters of contrast-enhanced ultrasound in prognosis of endometrial carcinoma |
| 投稿时间：2022-05-17 修订日期：2023-05-31 |
| DOI： |
| 中文关键词: 超声造影 血液灌注 子宫内膜癌 预后 |
| 英文关键词:Contrast-enhanced ultrasonography Blood perfusion Endometrial cancer Prognosis |
| 基金项目:浙江省基础公益研究计划项目(LGF20H180018) |
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| 中文摘要: |
| 目的 子宫内膜癌的发展和侵袭性与肿瘤血液灌注显著相关，本研究旨在评估子宫内膜癌术前超声造影（CEUS）定量灌注参数的预后价值。 方法 本研究纳入2016年1月至2021年1月期间112名术前行超声造影的子宫内膜癌患者。根据CEUS的时间-强度曲线（TIC）计算平均增强率ER（增强强度EI/上升时间RT）。平均随访34.6±9.7个月后，采用单因素和多因素COX回归分析ER值与术后总生存率（OS）和无病生存率（DFS）的相关性。结果 根据ROC曲线预测生存率的ER值最佳截断点值为1.8 dB/s。Kaplan-Meier生存曲线表明，ER值水平高的患者的DFS和OS比ER值水平低的患者更差（DFS：P<0.001；OS：P<0.05）。在多因素分析中，ER值被认为是子宫内膜癌患者复发（HR：1.68）和OS（HR：1.98）的独立预测因子（均P<0.05）。 结论 CEUS测量的定量灌注参数是子宫内膜癌术后生存率的重要预测因素。 |
| 英文摘要: |
| Objective The development and invasiveness of endometrial cancer are significantly correlated with tumor blood perfusion. This study aimed to evaluate the prognostic value of quantitative perfusion parameters of preoperative contrast-enhanced ultrasonography (CEUS) in endometrial cancer. Methods This study included 112 patients with endometrial cancer who underwent preoperative contrast-enhanced ultrasonography between January 2016 and January 2021. The average enhancement rate ER (enhancement intensity EI/rise time RT) was calculated from the time-intensity curve (TIC) of CEUS. After a mean follow-up of 34.6±9.7 months, univariate and multivariate COX regression was used to analyze the correlation of ER value with postoperative overall survival (OS) and disease-free survival (DFS). Results According to the ROC curve, the optimal cut-off point of ER value for predicting survival rate was 1.8 dB/s. Kaplan-Meier survival curves showed that patients with high ER value levels had worse DFS and OS than patients with low ER value levels (DFS: P<0.001; OS: P<0.05). In multivariate analysis, ER value was considered as an independent predictor of recurrence (HR: 1.68) and OS (HR: 1.98) in endometrial cancer patients (both P<0.05). Conclusion Quantitative perfusion parameters measured by CEUS are important predictors of postoperative survival for endometrial cancer. |
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