| 张伟,洪洋,陈晓菲,王晨晔,丁彩飞.益肾安宫Ⅱ号对脾肾两虚型复发性流产患者外周血可溶性Tim-3、Gal-9表达水平的影响[J].浙江中西医结合杂志,2023,33(6): |
| 益肾安宫Ⅱ号对脾肾两虚型复发性流产患者外周血可溶性Tim-3、Gal-9表达水平的影响 |
| Effects of Yishen Angong Prescription Ⅱ on Peripheral blood soluble Tim-3,Gal-9 expression levels in Patients with Recurrent Spontaneous Abortion of Spleen and Kidney Deficiency |
| 投稿时间：2022-06-16 修订日期：2022-10-28 |
| DOI： |
| 中文关键词: 复发性流产 益肾安宫Ⅱ号 可溶性Tim-3 Gal-9 |
| 英文关键词:Recurrent spontaneous abortion Yishen Angong prescription Ⅱ Soluble Tim-3 Gal-9 |
| 基金项目:杭州市医药卫生科技项目(编号：A20200084) 浙江省自然科学(编号：LY22H270001) |
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| 中文摘要: |
| 目的：观察益肾安宫Ⅱ对脾肾两虚型复发性流产（RSA）患者外周血sTim-3、Gal-9表达水平的影响，探讨益肾安宫Ⅱ号治疗RSA的作用机制。方法：RSA患者60例随机分为治疗组与对照组，每组各30例。对照组给予地屈孕酮片10mg 3/日 口服，治疗组加用益肾安宫Ⅱ号口服。另选正常妊娠早期女性30例为正常组。检测3组研究对象血清sTim-3、Gal-9、β-HCG、P、E2水平。结果：治疗组总有效率93.33%，明显高于对照组73.33%(P＜0.05)。治疗后，治疗组血清β-HCG及E2水平较治疗前显著上升（P＜0.05），且两者水平显著高于对照组（P＜0.05）。治疗后，治疗组与对照组sTim-3水平均较治疗前明显下降（P＜0.05），且治疗组明显低于对照组（P＜0.05）；治疗组与对照组Gal-9水平均较治疗前明显上升（P＜0.05），且治疗组明显高于对照组（P＜0.05）。结论：益肾安宫Ⅱ号对RSA患者血清β-HCG、E2水平上升有促进作用。经益肾安宫Ⅱ号干预后，RSA患者血清sTim-3水平下降，Gal-9水平上升，可降低流产风险，有益于妊娠结局。 |
| 英文摘要: |
| Objective: To observe the effect of Yishen Angong prescription Ⅱ on the expression levels of sTim-3 and Gal-9 in peripheral blood in patients with recurrent spontaneous abortion(RSA) with spleen and kidney deficiency，explore the mechanism of Yishen Angong prescription Ⅱ in the treatment of RSA. Methods：The 60 patients with RSA were randomly divided into treatment group and control group，30 cases in each group. The control group was given dydrogesterone tablets 10mg orally three times a day，the treatment group was supplemented with Yishen Angong prescription Ⅱ orally. Another 30 women in the first trimester of normal pregnancy were selected as the normal group. To detect the serum sTim-3，Gal-9，β-HCG，P，E2 levels in three groups of study subjects. Results: The total effective rate of the treatment group was 93.33%, which was significantly higher than that of the control group of 73.33% (P<0.05). After treatment, the serum β-HCG and E2 levels in the treatment group increased significantly compared with before treatment (P＜0.05), and the levels of both were significantly higher than those in the control group (P＜0.05). After treatment, the level of sTim-3 in the treatment group and the control group decreased significantly compared with before treatment (P<0.05), and the treatment group was significantly lower than that in the control group (P<0.05). The level of Gal-9 in the treatment group and the control group increased significantly compared with that before treatment (P<0.05), and the treatment group was significantly higher than that in the control group (P<0.05). Conclusions：Yishen Angong prescription Ⅱ has a promoting effect on the rise of serum β-HCG and E2 levels in patients with RSA. After Yishen Angong prescription Ⅱ intervention, serum sTim-3 levels decreased and Gal-9 levels increased in patients with RSA, which reduced the risk of miscarriage and benefited pregnancy outcomes. |
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