| 杨艳青,刘兰英.中药治疗青少年非自杀性自伤的用药及组方规律探析[J].浙江中西医结合杂志,2023,33(4): |
| 中药治疗青少年非自杀性自伤的用药及组方规律探析 |
| Analysis on the regularity of medication and prescription of traditional Chinese Medicine in the treatment of Adolescent non-suicidal self-injury |
| 投稿时间：2022-07-24 修订日期：2022-08-22 |
| DOI： |
| 中文关键词: 中药处方 非自杀性自伤 用药规律 疏肝健脾 |
| 英文关键词:prescription of traditional Chinese medicine non-suicidal self-injury medication rule soothing the liver and invigorating the spleen |
| 基金项目:重大疑难疾病中西医临床协作试点项目(国中医药办医政发〔2018〕3号),负责人:刘兰英；浙江省中医药防治重大疾病攻关计划项目(2018ZY001),病症结合治疗重性抑郁障碍诊疗新技术研究,负责人:刘兰英。浙江省卫生创新人才项目(浙卫办[2020]18号),负责人:刘兰英。 |
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| 中文摘要: |
| 目的 探讨中药治疗青少年非自杀性自伤的用药规律。方法 选取2021-02～2022-02期间在浙江省立同德医院住院治疗的青少年非自杀性自伤患者的中药处方资料。采用频数分析、关联规则分析、聚类分析挖掘核心用药及配伍特点。结果 90首方剂中涉及116味中药，使用频数最高的药物是柴胡；药性以平性（245次，36.03%）为主；药味以甘味（374次，31.11%）最多；归经以归脾经（491次，25.80%）最多。使用频数最高的药物类别是补虚药（316次，46.47%）。关联规则分析共得到药对6个，3味中药药组21个，具有代表性的规则有炒白芍—柴胡，柴胡–炒白芍–当归，炒白芍–麸炒白术–柴胡，体现了疏肝理气、养血健脾的治法特点。聚类分析提取得到3个核心处方，3个潜在处方均体现了疏肝解郁、健脾益气的治法特点。结论：通过对青少年非自杀性自伤患者的临床中药处方进行数据分析，能够明确核心中药，发现潜在的中药组方规律，推断主要病机和中医证型，为临床上运用中药治疗青少年非自杀性自伤提供一定参考。 |
| 英文摘要: |
| objective To explore the medication rule of traditional Chinese medicine in the treatment of non-suicidal self-injury in adolescents. Methods The traditional Chinese medicine prescription data of adolescent patients with non-suicidal self-injury who were hospitalized in Tongde Hospital of Zhejiang Province from February 2021 to February 2022 were selected.Frequency analysis, association rule analysis and cluster analysis were used to mine the characteristics of core drug use and compatibility.Result Among the 90 prescriptions, 116 traditional Chinese medicines were involved, and the drug with the highest frequency was Bupleurum; The most properties of drugs were flatness (245 times, 36.03%); the most taste of drugs were sweet (374 times, 31.11%); The most meridian tropism of drugs were Spleen meridian (491times, 25.80%). The category of drugs with the highest frequency of use was deficiency tonifying medicine (316 times, 46.47%). According to the analysis of association rules, there are 6 pairs of drugs and 21 groups of 3 kinds of traditional Chinese medicine. The representative rules are fried Radix Paeoniae Alba-Bupleurum, Radix Bupleuri-fried Radix Paeoniae Alba-Angelica, fried Radix Paeoniae Alba- Fried Atractylodes macrocephala Koidz-Bupleurum, which reflects the characteristics of treatment of soothing the liver and regulating qi, nourishing blood and invigorating the spleen. Three core prescriptions were extracted by cluster analysis, and this three potential prescriptions all reflected the therapeutic characteristics of soothing the liver and relieving depression, invigorating the spleen and replenishing qi. Conclusion Through the data analysis of the clinical prescriptions of traditional Chinese medicine in adolescent patients with non-suicidal self-injury, we can identify the core traditional Chinese medicine, find the potential prescription rules of traditional Chinese medicine, and infer the main pathogenesis and TCM syndrome types. to provide some reference for the clinical application of traditional Chinese medicine in the treatment of non-suicidal self-injury in adolescents. |
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