| 董玥,黄琦,汤军,沈淑华,田丰源,徐王达,方泽雨,张哲源,吴佳文.健脾祛浊方加减治疗痰湿型腹型肥胖伴糖耐量受损的临床效果观察[J].浙江中西医结合杂志,2023,33(5): |
| 健脾祛浊方加减治疗痰湿型腹型肥胖伴糖耐量受损的临床效果观察 |
| Clinical observation on the effect of Jianpi Quzhuo Decoction on the treatment of phlegm-dampness abdominal obesity with impaired glucose tolerance |
| 投稿时间：2023-01-31 修订日期：2023-03-21 |
| DOI： |
| 中文关键词: 腹型肥胖 糖耐量受损 痰湿证 健脾祛浊方 胰岛素抵抗 临床疗效 |
| 英文关键词:abdominal obesity impaired glucose tolerance phlegm-dampness Jianpi Quzhuo Decoction insulin resistance clinical efficacy |
| 基金项目:浙江省中医药现代化专项项目(2021ZX005) |
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| 中文摘要: |
| 目的：探讨健脾祛浊方治疗痰湿型腹型肥胖伴糖耐量受损的临床疗效及中医理论。方法：将69例患者随机分为治疗组和对照组。两组均给予一般性治疗持续两月，治疗组在对照组基础上口服健脾祛浊方加减。两组患者均连续治疗两个月，测量治疗前后腹围、臀围、身高、体重，计算体质量指数（BMI）、腰臀比（WHR）；检测治疗前后常规糖脂代谢指标，计算胰岛素抵抗指数（HOMA-IR）及TG/HDL-C；记录治疗前后中医证候评分并进行安全性评价。结果：治疗组患者经治疗后腹围、BMI、WHR均低于对照组（P＜0.05）；治疗组患者空腹血糖（FPG）、餐后2小时血糖（2hPG）、空腹胰岛素（FINS）、餐后2小时胰岛素（2hINS）、HOMA-IR、TG/HDL-C的改善均高于对照组（P＜0.01）；治疗组血脂各指标均低于对照组（P＜0.05）；治疗组中医证候评分的改善明显优于对照组（P＜0.01）。结论：健脾祛浊方加减治疗腹型肥胖伴糖耐量受损痰湿型患者，可以调节糖脂代谢，减缓胰岛素抵抗，作为常规中医组方治疗痰湿型腹型肥胖是可行的。 |
| 英文摘要: |
| Objective：To explore the clinical efficacy and TCM theory of modified Jianpi Quzhuo Decoction in the treatment of phlegm-dampness abdominal obesity with impaired glucose tolerance. Method：Sixty nine patients were randomly divided into treatment group and control group. Both groups were given general treatment for two months, and the treatment group was additionally given Jianpi Quzhuo Decoction. Patients in both groups were treated continuously for two months. Abdominal circumference, hip circumference, height and weight were measured before and after treatment, and body mass index (BMI) and waist-to-hip ratio (WHR) were calculated. Lipid and glucose metabolism indexes were detected before and after treatment, and insulin resistance index (HOMA-IR) and TG/HDL-C were calculated. The change of traditional Chinese medicine（TCM）syndrome scores before and after treatment was recorded and safety evaluation was carried out. Result: Abdominal circumference, BMI and WHR in treatment group were lower than those in control group (P < 0.05). The improvements of fasting plasma glucose（FPG）, 2 hour plasma glucose（2hPG）, fasting insulin（FINS）, 2 hour postprandial plasma insulin（2hINS）,HOMA-IR and TG/HDL-C in treatment group were higher than those in control group (P < 0.01). Indexes of blood lipid were lower than those in control group (P < 0.01). Amelioration of the TCM syndrome scores was better than those in control group (P < 0.01). Conclusion：Modified Jianpi Quzhuo Decoction can regulate glucose and lipid metabolism, improve IR, and it is feasible to treat phlegm-dampness abdominal obesity as a conventional TCM prescription. |
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