| 俞方泉,罗信国,王莉,蒋志勇,朱艳,叶虹位.自拟益气养血方对急性白血病化疗后粒细胞缺乏的疗效分析[J].浙江中西医结合杂志,2023,33(9): |
| 自拟益气养血方对急性白血病化疗后粒细胞缺乏的疗效分析 |
| Analysis of the effect of TCM Prescription for nourishing qi and blood on agranulocytosis after chemotherapy in acute leukemia |
| 投稿时间：2023-02-12 修订日期：2023-06-07 |
| DOI： |
| 中文关键词: 急性白血病 粒细胞缺乏 感染 中医药 益气养血 |
| 英文关键词:Acute Leukemia,Granulocyte deficiency,Infection,Traditional Chinese Medicine,Nourishing Qi and Blood |
| 基金项目:浙江省金华市科技计划项目(2021-4-302) |
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| 中文摘要: |
| 目的：探讨自拟益气养血方用于急性白血病初次诱导化疗后粒细胞缺乏阶段的临床疗效。方法：收集急性白血病初次诱导化疗后出现粒细胞缺乏病例共 80 例，其中纳入急性髓系白血病40例，急性淋巴细胞白血病40例，通过随机对照表将急性髓性白血病组和急性淋巴细胞白血病组皆分为对照组20例、观察组20例，对照组予以粒细胞集落刺激因子促进粒细胞恢复治疗，观察组在对照组治疗基础上加予中药汤剂自拟益气养血方加减化裁治疗。比较观察组与对照组治疗后的粒细胞缺乏持续时间、中性粒细胞最低数值、发热持续天数、发热次数、感染率、中医证候评分、西医疗效以及中医疗效等指标变化。结果：急性髓系白血病组和急性淋巴细胞白血病组两组中观察组治疗后粒细胞缺乏持续天数、中性粒细胞低下程度、发热持续天数、发热次数、感染率以及中医证候评分比对照组均明显下降（Ｐ＜0.05）；观察组与对照组西医疗效及中医疗效比较无明显差异（Ｐ＞0.05）。结论：应用自拟益气养血方可以促进急性白血病初次诱导化疗后粒细胞缺乏的恢复，降低感染发生率，改善临床症状，提高生活质量。 |
| 英文摘要: |
| Objective To investigate the clinical efficacy of nourishing qi and blood prescription for acute leukemia in the phase of agranulocytosis after initial induction chemotherapy. Method A total of 80 cases of agranulocytosis after initial induction chemotherapy for acute leukemia were collected, including 40 cases of acute myeloid leukemia and 40 cases of acute lymphoblastic leukemia. The acute myeloid leukemia group and the acute lymphoblastic leukemia group were divided into 20 cases in the control group and 20 cases in the observation group. The control group was treated with granulocyte colony-stimulating factor acupuncture to promote granulocyte recovery, and the observation group was treated with nourishing qi and blood prescription on the basis of the control group. The duration of agranulocytosis, the lowest value of neutrophils, the duration of fever, the number of fevers, the infection rate, the TCM syndrome score, the efficacy of western medicine and the efficacy of traditional Chinese medicine were compared between the observation group and the control group after treatment. Results The duration of agranulocytosis, the degree of neutropenia, the duration of fever, the number of fever, the infection rate and the TCM syndrome score in the observation group were significantly lower than those in the control group ( P < 0.05 ). There was no significant difference in the efficacy of western medicine and traditional Chinese medicine between the observation group and the control group ( P > 0.05 ). Conclusion The application of nourishing qi and blood prescription can promote the recovery of agranulocytosis after initial induction chemotherapy for acute leukemia, reduce the incidence of infection, improve clinical symptoms and improve the quality of life. |
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