| 宋晨,李军华,杨龙飞,罗显雁,彭建中.改良慢Mohs环状皮肤活检技术在阴茎阴囊Paget’s病的应用[J].浙江中西医结合杂志,2023,33(9): |
| 改良慢Mohs环状皮肤活检技术在阴茎阴囊Paget’s病的应用 |
| Application of modified slow mohs circular skin biopsy technique in Paget's disease of penile scrotum |
| 投稿时间：2023-03-03 修订日期：2023-05-03 |
| DOI： |
| 中文关键词: 阴茎阴囊paget’s病 肿瘤边界 皮肤活检技术 皮肤恶性肿瘤 |
| 英文关键词:paget's disease of penile scrotum Tumor boundary Modified circular skin biopsy technique with slow mohs Cutaneous malignancy |
| 基金项目:浙江省医药卫生科技计划(NO. 2022KY975) |
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| 中文摘要: |
| 目的：探讨改良慢mohs环状皮肤活检技术在术前确定阴茎阴囊乳房外Paget’s病患者肿瘤边界中的作用。方法：收集2015年1月至2022年12月杭州市第三人民医院泌尿外科36例阴茎阴囊Paget’s病患者。分为两组，分别采用不同的方法确定肿瘤的边界。对照组16例采用局部扩大切除法；观察组20例采用改良慢mohs环状皮肤活检技术确定肿瘤边界后行根治性切除术。统计分析患者手术时间、冰冻病理次数、外观功能满意度、功能性后遗症发生率及复发率等情况。结果：观察组术中冰冻病理次数、手术时间及复发率均明显低于对照组，差异有统计学意义（P<0.05）；观察组功能性后遗症发生率较低，患者对外观功能满意度高于对照组，差异有统计学意义（P<0.05）。结论：改良慢mohs环状皮肤活检技术能够在术前确定肿瘤边界，在保证完全切除病变组织的同时尽可能多地保留正常组织，从而减少术中冰冻时间、复发率及功能性后遗症的发生率，提高患者术后满意度。 |
| 英文摘要: |
| Objective: To investigate the role of modified slow mohs ring-shaped skin biopsy in preoperative determination of tumor boundaries in Paget's disease patients with extramammary penile scrotum. Methods: 36 patients with Paget's in penile scrotum were collected from the Department of Urology, Hangzhou Third People's Hospital from January 2015 to December 2022. They were divided into two groups, each using a different method to determine tumor boundaries. In control group, 16 cases were treated with local extended resection. Twenty patients in the observation group were treated with modified slow mohs ring-shaped skin biopsy to determine tumor boundaries and then underwent radical resection. The operative time, frozen pathological times, appearance and function satisfaction, incidence of functional sequelae and recurrence rate were analyzed statistically. Results: The number of intraoperative freezing pathology, operation time and recurrence rate in the observation group were significantly lower than those in the control group, and the difference was statistically significant (P< 0.05); The incidence of functional sequelae was lower in the observation group, and patients' satisfaction with appearance function was higher than that in the control group, the difference was statistically significant (P< 0.05). Conclusions: The modified circular skin biopsy technique of slow mohs can determine the tumor boundary before surgery and preserve as much normal tissue as possible while ensuring complete resection of the diseased tissue, thus reducing intraoperative freezing time, recurrence rate and incidence of functional sequelae, and improving postoperative satisfaction of patients. |
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