| 路晴晴,陈冻伢.薄荷油治疗肠易激综合征的有效性和安全性[J].浙江中西医结合杂志,2023,33(11): |
| 薄荷油治疗肠易激综合征的有效性和安全性 |
| Effectiveness and safety of peppermint oil in irritable bowel syndrome |
| 投稿时间：2023-03-30 修订日期：2023-09-14 |
| DOI： |
| 中文关键词: 薄荷油 肠易激综合征 疗效及安全性 Meta分析 |
| 英文关键词:Peppermint oil Irritable bowel syndrome Clinical efficacy and safety Meta-analysis |
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| 中文摘要: |
| 目的 评价薄荷油治疗肠易激综合征的有效性和安全性。方法 在PubMed、Cochrane library、Embase、Web of Science数据库中检索建库至2023年1月6号发表的有关薄荷油治疗肠易激综合征的文献。纳入薄荷油对比安慰剂治疗肠易激综合征的随机对照试验（RCTs）。结果 最终13项RCTs被纳入，共包含1054名肠易激综合征患者。薄荷油与安慰剂相比，整体症状改善率更高（RR=2.48，95％CI：1.98~3.10，P<0.001），对腹痛疗效更好（RR=1.69，95％CI：1.39~2.06，P<0.001），但不良反应也更多（RR=1.50，95％CI：1.09~2.08，P<0.05）。亚组分析显示，薄荷油的治疗效果并未随治疗时间的延长而增高，与长疗程组相比，短疗程组中患者整体症状改善率（RR=2.64，95％CI：1.80~3.87，P<0.05）、腹痛改善率（RR=1.96，95％CI：1.45~2.66，P<0.05）更高。结论 薄荷油可以有效改善IBS患者的整体症状和腹痛。但随着治疗时间的延长（＞4周），薄荷油的疗效反而减弱。因此，短期使用薄荷油（≤4周）患者获益更大。 |
| 英文摘要: |
| Objective To evaluate the efficacy and safety of peppermint oil in the treatment of irritable bowel syndrome (IBS). Methods We systematically searched the PubMed, Cochrane library、Embase and Web of Science for all applicable randomized controlled trials (RCTs) up to 6 January 2023. Results 13 randomized controlled studies with a total of 1054 irritable bowel syndrome patients were included. Peppermint oil had a higher overall symptom improvement rate than placebo (RR=2.48, 95％CI: 1.98~3.10, P<0.001), was more effective for abdominal pain (RR=1.69, 95％CI: 1.39~2.06, P<0.001), but also had more adverse effects (RR=1.50, 95％CI: 1.09~2.08, P<0.05). Subgroup analysis showed that the therapeutic effect of peppermint oil did not increase with the extension of treatment time. Compared with the long treatment group, the overall symptom improvement rate (RR=2.64, 95%CI: 1.80-3.87, P<0.05) and the improvement rate of abdominal pain in the short treatment group (RR=1.96, 95%CI: 1.45~2.66, P<0.05) higher. Conclusions Peppermint oil can significantly improve overall symptoms and abdominal pain in patients with IBS. However, with the extension of treatment time (> 4 weeks), the curative effect of peppermint oil decreased. Therefore, short-term use of peppermint oil (≤4 weeks) may benefit patients more than long-term use. |
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