| 张敏娜,吴侃,李嘉威,朱鲁程,王娇莉,夏冰,傅华洲,杨邵瑜,陈雪琴,马胜林.香草扶正合剂对非小细胞肺癌放化疗中医症候评分 和免疫功能影响研究[J].浙江中西医结合杂志,2023,33(9): |
| 香草扶正合剂对非小细胞肺癌放化疗中医症候评分 和免疫功能影响研究 |
| The effects of Xiangcao Fuzheng Mixture on TCM symptom score and immune function in non-small-cell lung cancer patients during radiochemotherapy |
| 投稿时间：2023-04-06 修订日期：2023-07-29 |
| DOI： |
| 中文关键词: 香草扶正合剂 非小细胞肺癌 放化疗 |
| 英文关键词:Xiangcao fuzheng Mixture Non-small cell lung cancer chemoradition |
| 基金项目:浙江省中医药防治重大疾病攻关计划项目（No.2018ZY009），浙江省自然科学基金青年项目（No.LQ20H160019），浙江中医药科技计划项目（No.2020ZB195） |
|
| 摘要点击次数: 562 |
| 全文下载次数: 19 |
| 中文摘要: |
| 摘要：目的 探讨香草扶正合剂对接受放化疗或化疗的中晚期非小细胞肺癌患者中医证候、免疫功能和临床疗效的影响。方法 纳入2018年12月至2021年10月收治的110例中晚期非小细胞肺癌患者，香草扶正组（香草扶正合剂联合放化疗或化疗）56例和对照组（放化疗或化疗）54例；比较两组治疗前后各项中医证候评分、免疫功能及两组间临床疗效的差异。结果 香草扶正组神疲乏力、咽干口燥、咳嗽、食欲减退及中医临床症状积分总分等症候群评分较基线下降，而对照组较基线升高，两组间治疗前后变化值具有显著性差异(P<0.05)；香草扶正组CD4+T细胞、CD8+T细胞及NK细胞亚群治疗前后比较，未见显著性差异(P>0.05)，而对照组治疗后CD4+T细胞、CD8+T细胞及NK细胞较治疗前显著下降，具有显著性差异(P<0.05)。香草扶正组客观有效率和疾病控制率分别为33.9%和92.9%，较对照组31.5%和81.5%，有提高趋势，但未见显著性差异(P>0.05)。结论 香草扶正合剂具有改善中晚期非小细胞肺癌放化疗或化疗患者中医证候评分和细胞免疫功能，且有提高疗效的趋势。 |
| 英文摘要: |
| Abstract: Objective To investigate the effects of Xiangcao Fuzheng Mixture on TCM (Traditional Chinese Medicine )syndrome, immune function and clinical efficacy of patients with advanced non-small cell lung cancer receiving chemoradiotherapy or chemotherapy. Methods A total of 110 patients with advanced NSCLC admitted from December 2018 to October 2021 were enrolled, including 56 cases in the Xiangcao Fuzheng group (Xiangcao Fuzheng mixture combined with chemoradiotherapy or chemotherapy) and 54 cases in the control group (chemoradiotherapy or chemotherapy). The differences of TCM syndrome scores, immune function and clinical efficacy between the two groups were compared before and after treatment. Results The scores of fatigue, dryness of pharynx, dryness of mouth, cough, loss of appetite and total scores of TCM clinical symptoms in the Xiangcao Fuzheng group were decreased compared with the baseline, while those in the control group were increased. The difference between the two groups before and after treatment was statistically significant (P<0.05).There was no statistical difference in CD4+T cells, CD8+T cells and NK cell subsets in the Xiangcao centralization group before and after treatment (P>0.05), while CD4+T cells, CD8+T cells and NK cells in the control group were significantly decreased after treatment, the difference was statistically significant (P<0.05).The objective effective rate and disease control rate of Xiangcao Fuxing group were 33.9% and 92.9%, respectively, compared with 31.5% and 81.5% in control group, but there was no statistical difference (P>0.05). Conclusions Xiangcao Fuzheng Mixture could improve the TCM syndrome score and cellular immune function in patients in local advanced or advanced non-small cell lung cancer with radiochemotherapy or chemotherapy, and has a trend of improving the response rate. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
