浙江中西医结合杂志

金信垚,潘沁瑜,周玉清,吴源鸿,谢明斌.益气养阴活血法治疗冠心病心律失常有效性和安全性的Meta分析*[J].浙江中西医结合杂志,2023,33(10):

益气养阴活血法治疗冠心病心律失常有效性和安全性的Meta分析*

Systematic Evaluation and Meta Analysis of the effectiveness and safety of the method of supplementing qi, nourishing yin, and promoting blood circulation in the treatment of coronary heart disease arrhythmias

投稿时间：2023-04-08 修订日期：2023-08-11

DOI：

中文关键词: 益气养阴活血法冠心病心律失常随机对照试验 Meta分析系统评价

英文关键词:strengthening qi, nourishing yin and activating the blood method Coronary heart disease Arrhythmia Randomized controlled trials Meta analysis system evaluation

基金项目:杭州市生物医药和健康产业发展扶持科技专项2021WJCY003

作者	单位	E-mail
金信垚	杭州市红十字会医院杭州	hz_jinxinyao@163.com
潘沁瑜	浙江中医药大学杭州
周玉清	宁波市北仑中医院宁波
吴源鸿	杭州市红十字会医院杭州
谢明斌^*	杭州市红十字会医院杭州	hz_xiemingbin@163.com

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中文摘要:

[摘要]目的系统评价益气养阴活血法治疗冠心病心律失常的有效性及安全性。方法检索中国知网数据库（CNKI）、维普中文科技期刊全文数据库（VIP）、中国学术期刊数据库（万方）、Cochrane图书馆、Web of Science和PubMed中有关益气养阴活血法治疗冠心病心律失常的临床随机对照试验研究，提取纳入研究的相关数据并进行方法学质量评价。应用RevMan5.3软件进行Meta分析。结果共纳入26个研究。Meta分析结果显示，益气养阴活血法治疗组在临床总有效率[OR=3.47，95%CI（2.68, 4.48），P<0.00001]、24h心律失常事件数[WMD=-204.82，95%CI（-228.78, -180.86），P<0.00001]、中医症候疗效[OR=3.08，95%CI（2.04,4.66），P<0.00001]、心电图疗效[OR=2.50，95%CI（1.63,3.83），P<0.0001]、血液流变学指标：全血高切黏度[WMD=-1.02，95%CI（-1.18，-0.85），P < 0.00001]、全血低切黏度值[WMD=-1.66，95%CI（-2.00，-1.33），P< 0.00001]、血浆比黏度[WMD=-0.42，95%CI（-0.50，-0.35），P < 0.00001]、纤维蛋白原[SMD=-1.67，95%CI（-2.06，-1.28），P <0.00001]及安全性[OR=0.41，95%CI（0.27,0.61），P<0.001]方面均优于常规西医治疗组。结论益气养阴活血法治疗冠心病心律失常具有更好的有效性及安全性。由于目前纳入文献数量及质量的限制，期望今后有更多高质量的随机对照试验支持。

英文摘要:

[Abstract] Objective To systematically evaluate the therapeutic effect of supplementing qi, nourishing yin, and promoting blood circulation method on coronary heart disease arrhythmias. Methods Databases of CNKI, VIP, Wanfang, Cochrane Liblary, Web of Science and PubMed were searched by computer to collect the clinical randomized controlled trials (RCT) of supplementing qi, nourishing yin, and promoting blood circulation method on coronary heart disease arrhythmias. The contents of the study were independently screened by two reviewers for qualified and qualified studies. After extracting data and evaluating risk bias，Revman 5.3 software was used for analysis. Results a total of 26 studies were included. The meta-analysis results showed that the trengthening qi, nourishing yin and promoting blood circulation method treated group exhibited significant improvement in the total clinical response rate[OR=3.47, 95%CI(2.68, 4.48), P<0.00001],the number of 24h arrhythmic events[WMD= -204.82, 95%CI(-228.78, -180.86），P<0.00001], the efficacy of traditional Chinese medicine syndrome[OR=3.08，95%CI（2.04,4.66），P<0.00001], the efficacy of electrocardiogram [OR=2.50，95%CI（1.63,3.83），P<0.0001], Hemorheological indexes: whole blood high cutting viscosity [WMD = -1.02, 95% CI (-1.18, - 0.85), P < 0.00001], whole blood low cutting viscosity value [WMD = -1.66, 95% CI (-2.00, - 1.33), P < 0.00001], plasma specific viscosity [WMD = -0.42, 95% CI (-0.50, - 0.35), P < 0.00001], Fibrinogen [SMD = -1.67, 95% CI (-2.06, - 1.28), P < 0.00001] and safety [OR=0.41，95%CI（0.27,0.61），P<0.001] were superior to those of the conventional western medicine group. Conclusion the treatment group using strengthening qi, nourishing yin and promoting blood circulation method was more superior than the conventional Western medical treatment group. Limited by the number and quality of included studies, it is expected that there will be more high-quality randomized controlled trials to support it in the future.

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