| 赵丹,杭金国,孙颖.小儿消积止咳口服液治疗对咳嗽变异性哮喘患儿肺通气功能及TIMP-1、IFN-γ、CysLTs水平的影响[J].浙江中西医结合杂志,2024,34(6): |
| 小儿消积止咳口服液治疗对咳嗽变异性哮喘患儿肺通气功能及TIMP-1、IFN-γ、CysLTs水平的影响 |
| Effect of Xiaoer Xiaoji Zhike oral liquid treatment on pulmonary ventilation function and levels of TIMP-1, IFN-γ and CysLTs in children with cough variant asthma |
| 投稿时间：2023-06-23 修订日期：2024-04-27 |
| DOI： |
| 中文关键词: 小儿消积止咳口服液 咳嗽变异性哮喘患儿 肺通气功能 基质金属蛋白酶组织抑因子-1 干扰素-γ 半胱氨酰白三烯 |
| 英文关键词:Xiaoer Xiaoji Zhike oral liquid Children with cough variant asthma Pulmonary ventilation function Tissue inhibitor of metallopoteinase 1 Interferon-γ Cysteinyl leukotrienes |
| 基金项目:台州市科技局科研项目 |
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| 中文摘要: |
| 目的 探讨小儿消积止咳口服液治疗对咳嗽变异性哮喘(CVA)患儿肺通气功能及基质金属蛋白酶组织抑因子-1(TIMP1)、干扰素-γ(IFN-γ)IFN-γ、半胱氨酰白三烯(CysLTs)水平的影响。方法 选取2020年3月～2023年3月期间在本院收治的122例CVA患儿,采取随机数字表法随机分为对照组和观察组,每组61例,对照组给予常规治疗(激素治疗、解痉平喘、化痰),观察组基于以上加予小儿消积止咳口服液,比较两组治疗前及治疗7d后的中医证候症状积分,评估两组临床疗效,对比两组治疗前及治疗7d后的肺通气功能[用力肺活量(FVC)、1s用力呼气容量(FEV1)、最大呼气峰流速(PEF)]、气道解剖学指标(气道壁厚度、基底膜厚度及气道壁总面积)、血清生化指标水平变化[TIMP1、IFN-γ、CysLTs]。结果 治疗7d后,两组中医证候症状积分较治疗前呈显著性下降(P<0.05),其中观察组显著低于对照组(P<0.05)；治疗7d后,观察组的临床总有效率显著高于对照组(88.52% VS 73.77%,P<0.05)；治疗7d后,两组FVC、FEV1、PEF均较治疗前有显著性提高(P<0.05),两组气道壁厚度、基底膜厚度及气道壁总面积均较治疗前有显著性减少(P<0.05),两组血清TIMP-1、CysLTs水平较治疗前有显著性降低(P<0.05),两组血清IFN-γ水平较治疗前有显著性提高(P<0.05),以上指标观察组变化幅度显著大于对照组(P<0.05)。结论 小儿消积止咳口服液治疗CVA患儿能明显改善相关症状,提高临床疗效,并利于肺通气功能提高,改善气道解剖结构,对血清TIMP1、CysLTs水平起到抑制作用,并上调血清IFN-γ水平,以改善病情。 |
| 英文摘要: |
| Objective To explore the effect of Xiaoer Xiaoji Zhike oral liquid on pulmonary ventilation function and levels of tissue inhibitor of metallopoteinase 1 (TIMP1), interferon-γ (IFN-γ) and cysteinyl leukotrienes (CysLTs) in children with cough variant asthma (CVA). Methods 122 children with CVA admitted to the hospital from March 2020 to March 2023 were selected and randomly divided into control group and observation group by the random number table method, with 61 cases in each group. The control group was given routine treatment (hormone therapy, spasmolysis and asthma relief, phlegm reduction), and the observation group was given Xiaoer Xiaoji Zhike oral liquid on this basis. The TCM syndrome score was compared between the two groups before treatment and after 7 days of treatment, and the clinical efficacy in the two groups was evaluated. The pulmonary ventilation function [forced vital capacity (FVC), 1s forced expiratory capacity (FEV1), peak expiratory flow rate (PEF)], airway anatomical indicators (airway wall thickness, basement membrane thickness and total airway wall area) and serum biochemical indicators (TIMP1, IFN-γ, CysLTs) were compared between the two groups before treatment and after 7 days of treatment. Results After 7 days of treatment, the score of TCM symptom in the two groups was significantly decreased compared with that before treatment (P<0.05), and the score in observation group was significantly lower than that in control group (P<0.05). The total clinical effective rate in observation group after 7 days of treatment was significantly higher than that in control group (88.52% VS 73.77%, P<0.05). After 7 days of treatment, the FVC, FEV1 and PEF in both groups were significantly increased compared with those before treatment (P<0.05), and the airway wall thickness, basement membrane thickness and total airway wall area were significantly reduced compared to before treatment (P<0.05), and the levels of serum TIMP-1 and CysLTs in the two groups were significantly declined compared with those before treatment (P<0.05) while the level of serum IFN-γ was significantly enhanced compared with that before treatment (P<0.05), and the changes of the above indicators in observation group were significantly greater than those in control group (P<0.05). Conclusion Xiaoer Xiaoji Zhike oral liquid in the treatment of children with CVA can obviously improve the related symptoms, enhance the clinical efficacy, help to enhance the pulmonary ventilation function, improve the airway anatomical structure, inhibit the levels of serum TIMP1 and CysLTs, and up-regulate the level of serum IFN-γ so as to improve the disease condition. |
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