| 李友青.舒更葡糖钠对老年脊柱手术患者术后肌松恢复的影响[J].浙江中西医结合杂志,2024,34(2): |
| 舒更葡糖钠对老年脊柱手术患者术后肌松恢复的影响 |
| Antagonistic effect of sodium gluconate on muscle relaxation in elderly patients after spinal surgery |
| 投稿时间：2023-07-04 修订日期：2023-10-02 |
| DOI： |
| 中文关键词: 舒更葡糖钠 脊柱手术 肌松 老年患者 |
| 英文关键词:Sodium gluconate Spinal surgery Muscle relaxation Elderly patient |
| 基金项目: |
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| 中文摘要: |
| 目的 分析舒更葡糖钠拮抗老年患者脊柱手术术后残余肌松的效果。 方法? 选取2021年7月至2022年7月在本院行脊柱手术的老年患者86例作为观察对象,采用随机数字表法分为舒更葡糖钠组(n=43例)和新斯的明组(n=43例)。两组麻醉诱导方式和术中维持方案相同,使用四个成串刺激(TOF)监测肌松。手术完成后,待肌松监测恢复到气管拔管30min时,舒更葡糖钠组给予舒更葡糖钠2mg/kg,新斯的明组术后给予甲硫酸新斯的明0.04mg/kg+阿托品0.02mg/kg。收集患者临床资料和麻醉手术相关指标。记录患者肌松拮抗起效时间、气管拔管时间、麻醉后监测治疗室(PACU)停留时间。统计患者给与肌松拮抗药后5min、15min、30min肌松残余率。 结果 两组患者性别、年龄、BMI、基础疾病、罗库溴铵用量、手术时间、出血量和输液量比较无明显差异(P>0.05)。舒更葡糖钠组气管拔管时间、肌松拮抗起效时间、PACU停留时间明显短于新斯的明组(P<0.05)。两组给与肌松拮抗药后5min、15min、30min肌松残余率,差异具有统计学意义(P<0.05)。 结论 舒更葡糖钠拮抗老年患者脊柱手术术后残余肌松的效果明确,减低了老年患者脊柱手术术后残余肌松的发生率、有利于患者早期康复,且安全性较高。 |
| 英文摘要: |
| Objective? To analyze the antagonistic effect of sodium gluconate on residual muscle relaxation in elderly patients after spinal surgery. Methods? A total of 86 elderly patients undergoing spinal surgery in the hospital were enrolled as observation objects between July 2020 and July 2022. According to random number table method, they were divided into sodium glycosylate group (n=43) and xinsi ming formation (n=43). The schemes of anesthesia induction and intraoperative maintenance were the same in the two groups, and muscle relaxation was monitored by train-of-four stimulation (TOF). When muscle relaxation monitoring was recovered to 30 minutes after tracheal extubation, sodium glycosylate group was given sodium gluconate (2mg/kg), while xinsi ming formation was given neostigmine methylsulfate (0.04mg/kg) + atropine (0.02mg/kg). The clinical data and anesthesia related indexes were collected. The antagonistic onset time of muscle relaxation, tracheal extubation time and stay time in post anesthesia care unit (PACU) were recorded. The residual rates of muscle relaxation at 5min, 15min and 30min after administration of muscle relaxation antagonists was statistically analyzed. Results? There was no significant difference in gender, age, BMI, underlying diseases, dosage of rocuronium bromide, operation time, blood loss or infusion volume between the two groups (P>0.05). The tracheal extubation time, antagonistic onset time of muscle relaxation and stay time in PACU in sodium glycosylate group were significantly shorter than those in xinsi ming formation (P<0.05). There were significant differences in residual rates of muscle relaxation at 5min, 15min and 30min after administration of muscle relaxation antagonists between the two groups (P<0.05). Conclusion Antagonistic effect of sodium gluconate is significant on residual muscle relaxation in elderly patients after spinal surgery, which reduce the incidence of residual muscle relaxation and is conducive to early recovery, with high safety. |
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