| 孟建标,刘昊,赖志珍,张亮.电针尺泽、上巨虚对ARDS患者血清Ang-1、Ang-2影响的临床研究：一项前瞻性随机对照试验[J].浙江中西医结合杂志,2024,34(4): |
| 电针尺泽、上巨虚对ARDS患者血清Ang-1、Ang-2影响的临床研究：一项前瞻性随机对照试验 |
| Clinical study on the effect of electroacupuncture at Chize and Shangjuxu on serum Ang-1 and Ang-2 in patients with ARDS: a prospective randomized controlled trial |
| 投稿时间：2023-07-08 修订日期：2024-02-16 |
| DOI： |
| 中文关键词: 急性呼吸窘迫综合征(ARDS) 电针 尺泽 上巨虚 血管生成素(Ang)-1 Ang-2 |
| 英文关键词:Acute respiratory distress syndrome (ARDS) Electroacupuncture Chize Shangjuxu Angiopoietin (Ang) -1 Ang-2 |
| 基金项目:浙江省中医药科技计划项目：2020ZB057 |
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| 中文摘要: |
| 目的:本研究旨在探讨电针尺泽、上巨虚对急性呼吸窘迫综合征(ARDS)患者血清Ang-1、Ang-2影响,明确电针对ARDS血管内皮是否存在保护作用。方法：将60例ARDS患者随机分为电针组、对照组和假针刺组,每组20例。对照组给予西医的针对ARDS的综合的常规治疗；电针组在常规治疗的基础上加用电针尺泽、上巨虚治疗；假针刺组在常规治疗基础上加用假针刺治疗(取穴同电针组)。电针组及假针刺组均每天治疗1次,连续治疗5天。分别于治疗前及治疗后第3、7天观察两组患者血清血管内皮生物标记物[血管生成素(Ang)-1及Ang-2]水平。并记录三患者机械通气时间、ICU住院时间及28天生存情况。结果：与本组治疗前比较,电针组患者治疗后第3天及第7天血清Ang-2水平均降低(均P＜0.05)。与本组治疗后第3天比较,电针组治疗后第7天血清Ang-2水平均无明显降低(均P＞0.05)。与对照组及假针刺组同期比较,电针组患者治疗后第3天及第7天血清Ang-2水平均较对照组及假针组降低(均P＜0.05),Ang-1水平均较对照组及假针刺组升高(均P＜0.05),假针刺组与对照组之间差异无统计学意义(均P＞0.05)。三组患者机械通气时间、住ICU时间以及28天病死率比较,差异无统计学意义(均P＞0.05)。结论：电针尺泽、上巨虚可以在降低ARDS患者血清Ang-2水平的同时升高Ang-1水平；具有保护ARDS患者血管内皮作用。 |
| 英文摘要: |
| Objective This study aims to investigate the effects of electroacupuncture on serum Ang-1 and Ang-2 in patients with acute respiratory distress syndrome (ARDS), and to clarify whether electroacupuncture has a protective effect on the vascular endothelium of ARDS. Methods 60 patients with ARDS were randomly divided into an electroacupuncture group, a control group, and a sham acupuncture group, with 20 cases in each group. Patients in control group received comprehensive routine treatment of Western medicine for ARDS. On the basis of conventional treatment of Western medicine, Patients in the electroacupuncture group were treated with electroacupuncture at Chize and Shangjuxu; The sham acupuncture group was treated with sham acupuncture(acupoint selection was the same as the electroacupuncture group) on the basis of routine treatment. Both the electroacupuncture group and the sham acupuncture group were treated once a day for 5 consecutive days. The levels of serum vascular endothelial Biomarker [angiopoietin-1 (Ang-1) and Ang-2] were detected before treatment and on the 3rd and 7th days after treatment. And we also recorded the days of mechanical ventilation, the length of stay in ICU, and survivals in 28 days of all patients in three groups. Results Compared with before treatment in this group, the serum Ang-2 levels in the electroacupuncture group decreased on the 3rd and 7th days after treatment (both P<0.05). Compared with the 3rd day after treatment in this group, there was no significant decrease in serum Ang-2 levels in the electroacupuncture group on the 7th day after treatment (all P>0.05). Compared with the control group and the sham acupuncture group during the same period, the serum Ang-2 levels of patients in the electroacupuncture group were lower than those of the control group and the sham acupuncture group on the 3rd and 7th day after treatment (all P<0.05), and the Ang-1 levels were higher than those of the control group and sham acupuncture group (all P<0.05). There was no statistically significant difference between the sham acupuncture group and the control group (all P>0.05). There was no statistically significant difference in mechanical ventilation time, ICU stay time, and mortality in 28 days among the three groups (all P>0.05). Conclusion: Electroacupuncture at Chize and Shangjuxu could reduce the serum Ang-2 level while increasing Ang-1 level in ARDS patients, and in might have a protective effect on vascular endothelium in ARDS patients. |
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