| 方平惠,谭帅,章利晨.祛瘀止痛合剂联合温经汤治疗寒凝血瘀型原发性痛经的临床研究[J].浙江中西医结合杂志,2024,34(2): |
| 祛瘀止痛合剂联合温经汤治疗寒凝血瘀型原发性痛经的临床研究 |
| Clinical Study of Quyu Zhitong Mixture Combined with Wenjing Decoction in Treating Primary Dysmenorrhea with Cold Coagulation and Blood Stasis |
| 投稿时间：2023-07-15 修订日期：2023-09-05 |
| DOI： |
| 中文关键词: 原发性痛经 寒凝血瘀证 祛瘀止痛合剂 温经汤 |
| 英文关键词:Primary dysmenorrhea Cold coagulation of blood stasis syndrome Quyu Zhitong Mixture Wenjing Decoction |
| 基金项目:金华市中医药科学技术研究计划项目 |
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| 中文摘要: |
| 目的:观察祛瘀止痛合剂联合温经汤对寒凝血瘀型原发性痛经的临床疗效。方法:对金华市中医医院2020年09月至2022年09月66例原发性痛经寒凝血瘀证患者采用随机数字表法分为两组,治疗组(33例)予祛瘀止痛合剂联合温经汤口服,对照组(33例)予布洛芬缓释胶囊口服,治疗3个月经周期,观察两组治疗前后及随访时(治疗结束3个月后)疼痛视觉模拟评分(VAS)、COX痛经症状量表(CMSS)评分、盆腔双侧子宫动脉血流情况［阻力指数(RI) 、搏动指数( PI) ］和不良反应情况。结果:治疗后治疗组有效率(87.9%)与对照组有效率(84.8%)相当(P＞0.05)；治疗结束3个月后随访时,治疗组有效率(72.7%)优于对照组(36.4%),差异有统计学意义(P＜0.05)。两组患者治疗后VAS评分均降低(P＜0.05),治疗组治疗结束3个月后随访时VAS评分较治疗前降低(P＜0.05),且低于对照组(P＜0.05)；对照组治疗结束3个月后随访时较治疗前无明显差异(P＞0.05)。治疗组治疗后及治疗结束3个月后随访时CMSS评分均较治疗前降低(P＜0.05)；且治疗组治疗后及治疗3个月后随访时CMSS评分均较对照组低(P＜0.05)。治疗组治疗后RI、PI值均较治疗前下降(P＜0.05),且治疗组治疗后RI、PI值均较对照组低(P＜0.05)。结论:祛瘀止痛合剂联合温经汤能有效缓解寒凝血瘀型患者经行腹痛症状,改善其盆腔微循环状态,提高患者舒适度。 |
| 英文摘要: |
| Objective: To observe the clinical effect of Quyu Zhitong mixture combined with Wenjing Decoction on primary dysmenorrhea with cold coagulation and blood stasis. Methods: From September 2020 to September 2022, 66 patients with primary dysmenorrhea syndrome of cold coagulation and blood stasis in Jinhua Hospital of Traditional Chinese Medicine were divided into two groups by random number table method. The treatment group (33 cases) was given Quyu Zhitong mixture combined with Wenjing Decoction orally, and the control group (33 cases) was given ibuprofen sustained release capsule orally for 3 menstrual cycles. Pain visual analogue scale (VAS), COX dysmorrhea Symptom Scale (CMSS) score, bilateral pelvic uterine artery blood flow [resistance index (RI), pulse index (PI)] and adverse reactions were observed before and after treatment and at follow-up (3 months after treatment). Results: After treatment the effective rate of treatment group (87.9%) was similar to that of control group (84.8%) (P > 0.05). Three months after the end of treatment, the effective rate of the treatment group (72.7%) was better than that of the control group (36.4%), and the difference was statistically significant (P < 0.05). The VAS score of both groups was decreased after treatment (P < 0.05), and the VAS score of the treatment group was lower than that of the control group (P < 0.05) at the follow-up 3 months after the end of treatment (P < 0.05). There was no significant difference in the control group at 3 months after treatment (P > 0.05). The CMSS score of the treatment group was lower after treatment and 3 months after the end of treatment than before treatment (P < 0.05). The CMSS score of the treatment group was lower than that of the control group after treatment and 3 months after treatment (P < 0.05). After treatment, the values of RI and PI in the treatment group were decreased compared with those before treatment (P < 0.05), and the values of RI and PI in the treatment group were lower than those in the control group (P < 0.05). Conclusion:Quyu Zhitong Mixture combined with Wenjing Decoction can effectively relieve the symptoms of abdominal pain in patients with cold coagulation and blood stasis during menstruation, improve the state of pelvic microcirculation and improve the comfort level of patients. |
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