| 施琳琳,陈芳,潘锋.结肠黑变病与中药互作及中医药防治研究进展[J].浙江中西医结合杂志,2024,34(6): |
| 结肠黑变病与中药互作及中医药防治研究进展 |
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| 投稿时间：2023-08-08 修订日期：2024-01-17 |
| DOI： |
| 中文关键词: 结肠黑变病 蒽醌类泻剂 辨证论治 |
| 英文关键词:Melanosis coli, Anthraquinone laxatives, syndrome differentiation and treatment |
| 基金项目:杭州市卫生科技计划(A20210146)；浙江省卫生健康科技计划(2022KY985)；杭州市生物医药和健康产业发展扶持科技专项(2022WJC203), |
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| 中文摘要: |
| 结肠黑变病( melanosis coli,MC) ,是一种良性结肠黏膜色素沉着性疾病,肠镜下表现为褐色或黑色豹纹样改变,组织学可见黏膜固有层巨噬细胞脂褐素过度聚集。虽然MC病因和发病机制不甚明确,但蒽醌类泻剂的长期服用已被认识到是其发病的关键因素。大量研究发现MC伴发结直肠腺瘤的发生率更高,但与结直肠癌的关系存在争议。对于MC的防治,中医辨证论治可以取得较好临床效果。本文将对MC的研究进展及中医治疗方案进行整理和综述。 |
| 英文摘要: |
| Melanosis coli (MC) known as a metabolic, benign colonic mucosal pigmentation disease, its colonic mucosal pigmentation was overlayed in macrophages of the lamina lamina by lipofuscin-like substances. The etiology and pathogenesis were unclear, but long-term use of anthraquinone laxative has been recognized as a key factor in its pathogenesis. A large number of studies have found that patients with MC seemed to accompanied by a higher incidence of colorectal adenoma, but its relationship with colorectal cancer remains controversial. For the prevention and treatment of MC, traditional Chinese medicine may achieve better clinical effect. In this paper, the research progress of MC and the treatment of traditional Chinese medicine will be summarized. |
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