| 赵倩倩,高祥福.基于铁死亡调控的中药活性成分在急性肾损伤治疗中的研究进展[J].浙江中西医结合杂志,2024,34(1): |
| 基于铁死亡调控的中药活性成分在急性肾损伤治疗中的研究进展 |
| Progress of active ingredients of traditional Chinese medicine based on ferroptosis regulation in the treatment of acute kidney injury |
| 投稿时间：2023-09-17 修订日期：2023-10-23 |
| DOI： |
| 中文关键词: 急性肾损伤 铁死亡 中药 活性成分 |
| 英文关键词:Acute kidney injury Ferroptosis Chinese medicine Active Ingredients |
| 基金项目: |
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| 中文摘要: |
| 近10年来,铁死亡作为一种非传统细胞死亡形式参与肾脏疾病的发生发展机制。在体内体外模型中,中药活性成分靶向调节铁死亡可以减轻肾小球、肾小管的损伤及肾间质纤维化,缓解急性肾损伤。在这里我们回顾了铁死亡参与AKI的机制,归纳中药活性成分调节铁死亡机制治疗不同类型急性肾损伤的途径,以期为中医药治疗急性肾损伤提供依据。 |
| 英文摘要: |
| Ferroptosis as a new regulatory cell death method that is involved in the development of kidney disease. In vivo and in vitro models, targeted regulation of ferroptosis by active ingredients of traditional Chinese medicine can attenuate glomerular and tubular injury and renal interstitial fibrosis, reduce acute kidney injury. This article reviews the pathway of ferropotosis involved in AKI, and summarize the pathways of TCM active ingredients regulating ferropotosis for the treatment of different types of acute kidney injury, with a view to providing a basis for the treatment of AKI with TCM. |
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