| 姚晓敏,张瑶佳.生化汤治疗稽留流产患者的临床研究[J].浙江中西医结合杂志,2024,34(7): |
| 生化汤治疗稽留流产患者的临床研究 |
| Clinical Study on the Treatment of Missed Abortion Patients with Shenghua Tang |
| 投稿时间：2023-10-02 修订日期：2024-04-23 |
| DOI： |
| 中文关键词: 生化汤 稽留流产 并发症 性激素 |
| 英文关键词:Biochemical soup Missed abortion complication Sex hormones |
| 基金项目:项目基金：浙江省医药卫生科技计划项目 编号：2023KY1183 |
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| 中文摘要: |
| 目的 探讨生化汤治疗稽留流产患者的效果观察。方法 选择本院2022年6月-2023年6月间收治的77例稽留流产患者作为研究对象,采用随机数字表法将患者分为观察组(39例)与对照组(38例)。对照组采用米非司酮联合米索前列醇治疗；在此基础上,观察组加用生化汤治疗,比较2组治疗后阴道流血时间、人绒毛膜促性腺激素(HCG)恢复时间、经期复潮时间、并发症；比较2组治疗前后炎症因子[白介素-6(IL-6)、C反应蛋白(CRP)]、性激素[促黄体生成素(LH)、促卵泡激素(FSH)、雌二醇(E2)]。结果 治疗后,观察组疗效94.87%高于对照组78.95%,差异有统计学意义(P＜0.05)。观察组阴道流血时间8.10±1.55(d)、HCG恢复时间9.26±0.72(d) 、月经复潮时间34.26±3.40(d)少于对照组阴道流血时间11.29±1.90(d)、HCG恢复时间11.04±1.49(d)、月经复潮时间38.47±4.19(d),差异有统计学意义(P＜0.05)。治疗后,观察组FSH(5.12±0.31)U/L、LH(11.22±1.56)U/L以及E2(255.20±20.66)mg/L水平低于对照组FSH(6.11±0.52)U/L、LH(12.16±1.27)U/L以及E2(310.25±19.36)mg/L水平,差异有统计学意义(P＜0.05)。治疗后,观察组IL-6(18.11±2.12)mg/L、CRP(6.11±2.11)ng/L水平低于对照组IL-6(20.17±1.89)mg/L、CRP(7.69±2.14)ng/L,差异有统计学意义(P＜0.05)。观察组不良反应发生率7.69%低于对照组26.32%,差异有统计学意义(P＜0.05)。结论 生化汤通可以有效缩短稽留流产患者阴道流血、经期复潮以及HCG恢复时间,减少并发症发生,降低炎症因子及性激素水平。 |
| 英文摘要: |
| Objective Exploring the therapeutic effect of Shenghua Tang on missed miscarriage patients. Methods 77 patients with missed abortion admitted from June 2022 to June 2023 were selected as the study subjects. The patients were randomly divided into observation group and control group. The control group was treated with mifepristone combined with misoprostol; On this basis, the observation group was treated with Shenghua Decoction, and the vaginal bleeding time, the recovery time of human chorionic gonadotropin (HCG), the embryo sac excretion time, the menstrual rehydration time, and the complications were compared between the two groups; The endometrial thickness, inflammatory factors [interleukin-6 (IL-6), C-reactive protein (CRP)], sex hormones [luteinizing hormone (LH), follicle stimulating hormone (FSH), estradiol (E2)] were compared between the two groups before and after treatment. Results After treatment, the curative effect of the observation group was 94.87% higher than that of the control group (78.95%), with a statistically significant difference (P<0.05). The observation group had a shorter vaginal bleeding time of 8.10 ± 1.55 (d), HCG recovery time of 9.26 ± 0.72 (d), and menstrual regain time of 34.26 ± 3.40 (d) compared to the control group"s vaginal bleeding time of 11.29 ± 1.90 (d), HCG recovery time of 11.04 ± 1.49 (d), and menstrual regain time of 38.47 ± 4.19 (d), with statistically significant differences (P<0.05). After treatment, the levels of FSH (5.12 ± 0.31) U/L, LH (11.22 ± 1.56) U/L, and E2 (255.20 ± 20.66) mg/L in the observation group were lower than those in the control group (6.11 ± 0.52) U/L, LH (12.16 ± 1.27) U/L, and E2 (310.25 ± 19.36) mg/L, with statistical significance (P<0.05). After treatment, the levels of IL-6 (18.11 ± 2.12) mg/L and CRP (6.11 ± 2.11) ng/L in the observation group were lower than those in the control group (20.17 ± 1.89) mg/L and CRP (7.69 ± 2.14) ng/L, with statistical significance (P<0.05). The incidence of adverse reactions in the observation group was 7.69% lower than that in the control group (26.32%), with a statistically significant difference (P<0.05). Conclusion Shenghua Tangtong can effectively shorten the vaginal bleeding, embryo sac discharge, menstrual rehydration and HCG recovery time of missed abortion patients, reduce complications, increase endometrial thickness, and reduce the level of inflammatory factors and sex hormones. |
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