| 王晓翔,池恒愉,康玉蓉,寿升芸,何晓芬.嘌呤受体P2X4介导慢性疼痛的研究进展[J].浙江中西医结合杂志,2024,34(8): |
| 嘌呤受体P2X4介导慢性疼痛的研究进展 |
| Research progress of purine receptor P2X4 involved in chronic pain |
| 投稿时间：2023-10-08 修订日期：2024-01-09 |
| DOI： |
| 中文关键词: 慢性疼痛 嘌呤受体P2X4 神经病理痛 炎性痛 癌性痛 内脏痛 |
| 英文关键词:Chronic pain Purinergic receptor P2X4 Neuropathic pain Inflammatory pain Cancer pain Visceral pain |
| 基金项目:国家自然科学基金项目（面上项目，重点项目，重大项目） |
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| 中文摘要: |
| 慢性疼痛是一种临床常见病症,发病机制复杂,目前临床上尚缺乏效佳、毒副作用少、针对性强的治疗方法,对慢性疼痛病理机制的研究仍然是目前疼痛研究领域的热点。嘌呤受体激活与疼痛调制机制密切相关,嘌呤受体 P2X 配体门控离子通道 4 (purinergicreceptor P2X ligand-gated ion channel 4,P2X4R)作为嘌呤受体家族的重要成员之一,在慢性疼痛的发生发展中发挥着重要作用。近年来研究发现,P2X4R在神经病理痛、炎性痛、癌性痛及内脏痛等慢性疼痛的形成、传导和调节中均发挥关键作用。本文就有关P2X4R在不同类型慢性疼痛中的作用及相关研究进展做一综述。 |
| 英文摘要: |
| Chronic pain is a common clinical disease with complex pathogenesis. At present, there is still a lack of effective, less toxic and side effects, targeted therapeutic methods. The study on the pathological mechanism of chronic pain is still a hot spot in the field of pain research. Purine receptor activation is closely related to the mechanism of pain modulation. As one of the vital members of the purine receptor family, P2X4R is of great importance in the occurrence and development of chronic pain. Recent research suggest that P2X4R plays a key role in the formation, transmission and modulation of chronic pain, such as neuropathic pain, inflammatory pain, cancer pain and visceral pain. In this article,the role and related mechanism of P2X4R in different types of chronic pain are reviewed. |
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