| 丁少杰,冯志杰,王鑫,吉学群.针刺与选择性五羟色胺再摄取抑制剂治疗脑卒中后抑郁疗效对比的Meta分析[J].浙江中西医结合杂志,2024,34(9): |
| 针刺与选择性五羟色胺再摄取抑制剂治疗脑卒中后抑郁疗效对比的Meta分析 |
| Efficacy of Acupuncture versus SSRIs in the Treatment of Post-stroke Depression: a Meta-analysis |
| 投稿时间：2023-12-06 修订日期：2024-03-23 |
| DOI： |
| 中文关键词: 脑卒中后抑郁 针刺 SSRIs Meta分析 随机对照试验 |
| 英文关键词:PSD Acupuncture SSRIs Meta-analysis Randomized controlled trial |
| 基金项目: |
|
| 摘要点击次数: 786 |
| 全文下载次数: 2 |
| 中文摘要: |
| 目的 系统评价针刺对比SSRIs治疗脑卒中后抑郁（PSD）的疗效差异。方法 计算机检索CNKI、Wan-Fang Database、VIP、CBM、PubMed、Embase、Web of Science和Cochrane Library等数据库，搜集针刺对比SSRIs治疗PSD的随机对照试验（RCT），检索时限均为建库至2022年8月7日。2名研究人员独立完成文献筛选、数据提取及偏倚风险评估，采用RevMan 5.3和Stata15.0软件进行Meta分析。结果 共纳入22个RCT，包括1927例患者。Meta分析初步结果显示，单纯针刺较SSRIs可提高PSD患者临床总有效率[RR=1.14,95%CI(1.09,1.20),Z=5.77,P＜0.001]和Barthel指数评分[WMD=16.93,95%CI(14.06,
19.80),Z=11.57,P＜0.001]。在改善HAMD评分方面，9项研究结果显示单纯针刺较SSRIs可降低HAMD-17项评分，1项研究结果显示SSRIs效果更佳，2项研究显示两者差异无统计学意义；同时，两者在改善HAMD-24项评分上差异无统计学意义([WMD=-0.61,95%CI(-1.43,-0.21),Z=1.46,P=0.144])。敏感性分析结果显示，单纯针刺较SSRIs可降低HAMD-24项评分[WMD=-0.78,95%CI(-1.32,-0.24),Z=2.83,P=0.005]。结论 现有证据表明，单纯针刺和SSRIs在改善PSD患者抑郁状态上疗效相当，而在提高临床总有效率及日常生活能力方面，单独针刺则具有一定优势。因受纳入研究数量及质量影响，上述结论仍需进一步验证。 |
| 英文摘要: |
| Objectives Systematically review of the difference in the efficacy of acupuncture versus SSRIs in the treatment of post-stroke depression (PSD). Methods CNKI、Wan-Fang Database、VIP、CBM、PubMed、Embase、Web of Science and Cochrane Library were electronically searched to collect randomized controlled trial (RCT) on acupuncture and SSRIs for PSD from inception to August 7,2022. Two reviewers independently screened literature, extracted data and assessed risk of bias of included studies, then meta-analysis was performed by using Rev Man 5.3 and Stata 15.0 software. Results A total of 22 RCTs involving 1927 patients were included. The preliminary results of the meta-analysis showed that compared with SSRIs, acupuncture can increase the total clinical effective rate of PSD patients[RR=1.14,95%CI(1.09, |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
