| 陈方军.透脓散口服对肛周脓肿切开引流术热毒蕴结证患者IL-6、5-HT、PGE2及免疫功能的影响[J].浙江中西医结合杂志,2025,35(2): |
| 透脓散口服对肛周脓肿切开引流术热毒蕴结证患者IL-6、5-HT、PGE2及免疫功能的影响 |
| Effects of Tsing Ji SAN oral administration on IL-6, 5-HT, PGE2 and immune function in patients with perianal abscess incision and drainage (syndrome of heat toxicity accumulation) |
| 投稿时间：2024-01-23 修订日期：2024-09-14 |
| DOI： |
| 中文关键词: 透脓散 肛周脓肿切开引流术 热毒蕴结证 IL-6 5-HT 免疫功能 症状积分 切口愈合情况 |
| 英文关键词:Tsing Ji SAN Incision and drainage of perianal abscess Syndrome of heat toxicity accumulation IL-6 5-HT Immune function Symptom score Wound healing |
| 基金项目: |
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| 中文摘要: |
| 目的:探讨透脓散口服在肛周脓肿切开引流术患者(热毒蕴结证)治疗中的应用价值。方法:所有肛周脓肿均于2021年12月至2023年7月在我院就诊并随机分组,两组75例,均行切开引流术,中医证型均为热毒蕴结证,术后对照组采用常规西医治疗,观察组联合透脓散口服治疗,治疗8周后比较疗效。结果:治疗后观察组血清C反应蛋白(C-reactive Protein,CRP)、白介素-6(interleukin-6,IL-6)、五羟色胺(Serotonin,5-HT)、前列腺素E2(Prostaglandin E2,PGE2)低于对照组,差异具统计学意义(P<0.05)；治疗后观察组血清免疫球蛋白G(immunoglobulin G,IgG)、CD4+细胞、CD4+/CD8+等免疫指标水平更高(P<0.05)；治疗后观察组中医总症状积分更低,治疗后7d及14d时的肉芽评分及创面缩小率更高(P<0.05)；治疗后观察组创面愈合时间、住院时间更低(P<0.05)；观察组总有效率97.33%(73/75),高于对照组的85.33%(64/75)(P<0.05)。结论:对于肛周脓肿切开引流术患者(热毒蕴结证)而言联合透脓散口服治疗有助于减轻炎症反应,改善免疫功能,促进切口愈合,且提高临床疗效。 |
| 英文摘要: |
| Objective: To investigate the application value of Tinjusan oral in the treatment of perianal abscess incision and drainage (syndrome of heat toxicity accumulation). Methods: All perianal abscesses were treated in our hospital from December 2021 to July 2023 and randomly divided into two groups, 75 cases were treated with incision and drainage, and the traditional Chinese medicine syndrome was heat toxicity accumulation syndrome. The control group was treated with conventional Western medicine after surgery, and the observation group was treated with oral treatment combined with Tinjusan, and the curative effect was compared after 8 weeks of treatment. Result: After treatment, the serum C-reactive Protein (CRP), interleukin-6 (IL-6), Serotonin (5-HT) and Prostaglandin E2 (PGE2) in the observation group were lower than those in the control group. The difference was statistically significant (P<0.05). After treatment, the levels of immunoglobulin G(IgG), CD4+ cells, CD4+/CD8+ and other immune indexes in the observation group were higher (P<0.05). After treatment, the total symptom score of TCM in the observation group was lower, and the granulation score and wound reduction rate were higher at 7d and 14d after treatment (P<0.05). After treatment, the wound healing time and hospital stay in the observation group were lower (P<0.05). The total effective rate of the observation group was 97.33% (73/75), which was higher than that of the control group (85.33% (64/75) (P<0.05). Conclusion: For patients with perianal abscess incision and drainage (heat toxin accumulation syndrome), combined with oral treatment of TJS can reduce inflammation, improve immune function, promote incision healing, and improve clinical efficacy. |
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