| 胡娅娜,章雄英,陈衍.裘氏滋阴熄风汤联合西药治疗肝肾不足型早中期帕金森病的临床研究[J].浙江中西医结合杂志,2024,34(10): |
| 裘氏滋阴熄风汤联合西药治疗肝肾不足型早中期帕金森病的临床研究 |
| Clinical Study on the Combination of Qiushi Ziyin Xifeng Tang and Dopamine Hydrazine in the Treatment of Early and Middle Stage Parkinson's Disease with Liver and Kidney Deficiency |
| 投稿时间：2024-03-01 修订日期：2024-09-11 |
| DOI： |
| 中文关键词: 帕金森病 裘氏滋阴熄风汤 氧化应激 炎症因子 肝肾不足 |
| 英文关键词:Parkinson"s Dsease Qiu Shi Zi Yin Xi Feng Tang Oxidative Sress Inflammatory Fctors Kidney Dficiency Tpe |
| 基金项目:2022年金华市中医药科学技术研究计划项目 编号：2022KY22 |
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| 中文摘要: |
| 目的:观察裘氏滋阴熄风汤联合多巴丝肼治疗肝肾不足型早中期帕金森病的临床疗效。方法:选取2022年1月~2023年6月收治的60例肝肾不足型早中期帕金森病患者作为研究对象,随机分为两组各30例。在常规治疗的基础上,对照组口服多巴丝肼片,观察组予裘氏滋阴熄风汤联合多巴丝肼片治疗,疗程为12周。比较两组的临床疗效与不良反应。结果:观察组总有效率86.7%,高于对照组的70.0%(p<0.05)。两组中医证候积分、UPDRS均较治疗前下降(p<0.05),且观察组评分改善情况均优于对照组(p<0.05)。治疗后,两组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、血清丙二醛(MDA)水平较治疗前降低(p<0.05),超氧化物歧化酶(SOD)水平较治疗前升高(p<0.05),且观察组TNF-α、IL-1β、MDA水平低于对照组(p<0.05),SOD水平高于对照组(p<0.05)。对照组出现不良反应3例,其中腹部不适2例,头晕恶心1例；观察组出现不良反应2例,其中腹部不适和心悸各1例,两组不良反应发生率无显著性差异(p>0.05)。结论:裘氏滋阴熄风汤联合多巴丝肼片治疗肝肾不足型早中期帕金森病效果显著,可减轻临床症状、拮抗氧化应激、减轻炎症反应,且安全性好。 |
| 英文摘要: |
| Objective: To observe the clinical efficacy of Qiu"s Ziyin Xifeng Tang combined with dopamine hydrazine in the treatment of early and middle stage Parkinson"s disease with liver and kidney deficiency. Method: Sixty patients with early to mid stage Parkinson"s disease with liver and kidney deficiency admitted from January 2022 to June 2023 were selected as the study subjects, and randomly divided into two groups with 30 cases in each group. On the basis of conventional treatment, the control group was treated with dopamine hydrazine tablets, while the observation group was treated with Qiu"s Ziyin Xifeng Tang combined with dopamine hydrazine tablets for 12 weeks. Compare the clinical efficacy and adverse reactions between two groups. Result: The total effective rate of the observation group was 86.7%, higher than the control group"s 70.0% (p<0.05). The scores of traditional Chinese medicine syndromes and UPDRS in both groups decreased compared to before treatment (p<0.05), and the improvement in scores in the observation group was better than that in the control group (p<0.05). After treatment, two groups of serum tumor necrosis factor- α (TNF)- α)、 Interleukin-1 β (IL-1) β)、 The level of serum malondialdehyde (MDA) decreased compared to before treatment (P<0.05), and the level of superoxide dismutase (SOD) increased compared to before treatment (P<0.05), with TNF in the observation group- α、 IL-1 β、 The MDA level was lower than the control group (P<0.05), and the SOD water level was higher than the control group (P<0.05). There were 3 cases of adverse reactions in the control group, including 2 cases of abdominal discomfort and 1 case of dizziness and nausea; There were 2 cases of adverse reactions in the observation group, including 1 case of abdominal discomfort and 1 case of palpitations. There was no significant difference in the incidence of adverse reactions between the two groups (p>0.05). Conclusion: The combination of Qiushi Ziyin Xifeng Tang and Dosiazid tablets has a significant effect on the treatment of early and middle stage Parkinson"s disease with liver and kidney deficiency. It can alleviate clinical symptoms, antagonize oxidative stress, alleviate inflammatory reactions, and has good safety. |
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