| 卢一斌,马效东,姚斌.基层医院运用健脾补肺法治疗小儿腺样体肥大的疗效观察[J].浙江中西医结合杂志,2024,34(10): |
| 基层医院运用健脾补肺法治疗小儿腺样体肥大的疗效观察 |
| Observation on the curative effect of invigorating spleen and invigorating lung in children with adenoid hypertrophy in primary hospital |
| 投稿时间：2024-03-01 修订日期：2024-08-07 |
| DOI： |
| 中文关键词: 腺样体肥大 健脾补肺法 炎症细胞因子 变态反应 疗效观察 |
| 英文关键词:adenoid hypertrophy Invigorating spleen and tonifying lung Inflammatory cytokines Allergic reaction Curative effect observation |
| 基金项目:杭州市卫生科技计划一般项目(No.B20220817) |
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| 中文摘要: |
| 摘要：目的 观察中医健脾补肺法治疗肺脾气虚型小儿腺样体肥大的疗效。方法 选取杭州市余杭区第三人民医院儿科2022年5月～2023年4月期间就诊的肺脾气虚型腺样体肥大患儿60例，以随机数字表法分为观察组及对照组各30例。观察组予中药汤剂健脾补肺；对照组给予糠酸莫米松喷鼻剂和孟鲁司特钠治疗，两组治疗4周，并对两组治疗前后主要症状积分，腺样体体积，炎症细胞因子及变态反应指标及疗效进行临床评价。结果 治疗后两组患儿鼻塞、打鼾、张口呼吸三项指标的症状积分及症状总积分明显降低，与同组治疗前比较，有显著性差异（P ＜0.01），且观察组下降更明显（P ＜0.05）；治疗后两组腺样体体积明显缩小，与同组治疗前比较，有显著性差异（P ＜0.01），且观察组下降更明显（P ＜0.05）。治疗后两组炎症细胞因子LTC4、LTD4、TNF－α及变态反应指标ECP、EOS和sIgE明显降低，与同组治疗前比较，有显著性差异（P ＜0.01），且观察组下降更明显（P ＜0.05）。观察组总有效率明显高于对照组，且有显著性差异（P ＜0.05）。结论 健脾补肺法治疗小儿肺脾气虚型腺样体肥大效果明显，可缓解其炎性状况，调控机体的免疫稳态，进而达到改善患儿临床症状的效果，与西医治疗相比，疗效更佳，且方法安全可靠，临床上具有一定的推广价值。 |
| 英文摘要: |
| Abstract: Objective：To observe the therapeutic effect of traditional Chinese medicine invigorating spleen and invigorating lung on adenoid hypertrophy in children with spleen-qi deficiency.
Method: A total of 60 children with lung Qi deficiency type adenoid hypertrophy were selected from the department of pediatric of the Third People's Hospital of Yuhang District, Hangzhou , who were admitted from May 2022 to April 2023,then they were divided into observation group (30 cases) and control group (30 cases) according to random number table method. Observation group was given traditional Chinese medicine decoction to strengthen spleen and tonify lung; the control group was treated with Mometasone furoate nasal spray(MFNS) combined with Montelukast sodium chewable tablets,the two groups were treated for 4 weeks, then the main symptom scores, adenoid volume, inflammatory cytokines and allergic indicators before and after treatment were evaluated.
Result: After treatment, the individual symptom score of nasal congestion、snoring、open mouth breathing were significantly decreased as while as the total score of symptoms in the two groups , and the difference was statistically significant compared with before treatment (P < 0.05), and the decrease was more significant in the observation group (P < 0.05). After treatment, the volume of adenoids in the two groups decreased significantly, and the difference was statistically significant compared with that before treatment (P < 0.05), and the decrease was more significant in the observation group (P < 0.05). Inflammatory cytokines LTC4, LTD4, TNF-α and allergy indicators ECP, EOS and sIgE were significantly decreased in the two groups after treatment, and the difference was statistically significant compared with before treatment (P < 0.05), and the decrease was more significant in the observation group (P < 0.05).The total effective rate of the observation group was significantly higher than that of the control group, and the difference was statistically significant (P < 0.05).
Conclusion: The therapeutic effect of invigorating spleen and invigorating lung in the treatment of adenoid hypertrophy of lung qi deficiency in children is significant, which can alleviate the inflammatory state, regulate the immune homeostasis of the body, and thus improve the clinical symptoms of children. Compared with western medicine treatment, the curative effect is better, and the method is safe and reliable, and has certain clinical promotion value. |
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