浙江中西医结合杂志

谢浩然,余玉宏,赵戊辰,方礼逵,朱燕珍,郑红,叶波.MSCs联合天然中药植物黄酮治疗慢性压疮的疗效分析[J].浙江中西医结合杂志,2024,34(11):

MSCs联合天然中药植物黄酮治疗慢性压疮的疗效分析

MSCs and Chinese herbal plant flavonoids complex for the treatment of chronic pressure ulcer wounds

投稿时间：2024-03-08 修订日期：2024-09-13

DOI：

英文关键词:MSCs–PEs pressure ulcers flavonoids hospitalized elderly patients.

基金项目:杭州市科学技术局(No. 2021WICY060)

作者	单位	E-mail
谢浩然	浙江中医药大学	tingfengaxhr@163.com
余玉宏	杭州曼迪生物科技有限公司
赵戊辰	杭州市红十字会医院
方礼逵	杭州市红十字会医院
朱燕珍	杭州市红十字会医院
郑红	杭州市红十字会医院
叶波^*	杭州市红十字会医院	yeboboye@126.com

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中文摘要:

目的: 本研究旨在观察间充质干细胞复合生长因子组联合天然中草药植物类黄酮复合物对老年患者慢性压疮伤口愈合再生修复的临床治疗效果。方法:选取2021年9月至2022年11月于杭州市红十字会医院胸外科住院的慢性压疮患者，采用随机数字表法将患者随机分为对照组和治疗组。对照组每天常规换药1次，用生理盐水冲洗创面，清除坏死组织和渗出液，用聚维酮碘常规消毒创面，并覆盖无菌纱布，持续4周。治疗组在常规换药的基础上，治疗组患者按每1mL/10cm2的原则将MSCs-PEs产品均匀涂抹于压疮伤口上，每日1次，疗程为4周。使用Bates-Jensen伤口评估工具(BWAT)在治疗周期的第0至4周对压疮伤口进行评估。结果：最终44例患者完成该试验，其中对照组22例，治疗组22例。与基线相比，治疗周期的第1到4周内，治疗组BWAT评分显著下降[-6.5(-7.9,-5.1),P < 0.05; -11.6(-13.4,-9.9),P < 0.05; 13(-15.1,-10.9),P < 0.05; -15.6(-17.9,-13.3),P < 0.05]，对照组BWAT评分略微升高[0.1(-1.2,1.4),P＞0.05; 1.3(-0.4,3.8),P＞0.05; 5.2(2.8,7.6),P＞0.05; 3.1(0.4,5.9),P＞0.05]；治疗组和对照组BWAT评分对比，在第2周已有显著差异(-12.9(-15.9,-10.7)，P < 0.05)，在第4周两组BWAT评分差异进一步扩大(-14.3(-22.2,-15.3)，P < 0.05)。结论: MSCs–PEs对慢性压疮伤口的愈合具有显著的效果，仅常规换药不利于慢性压疮伤口的愈合。

英文摘要:

Objective: This study aims to see how well mesenchymal stem cells composite growth factor groups and natural Chinese herbal plant flavonoid complexes worked on pressure ulcer wounds in elderly patients. Methods: The study’s methology was a randomized controlled trial. From September 2021 to November 2022, patients with chronic pressure ulcers at Hangzhou Red Cross Hospital, were randomly assigned to one of two groups: control or treatment. The control group only used conventional wound dressing change, once a day, whereas the treatment group used mesenchymal stem cells composite growth factor groups and natural Chinese herbal plant flavonoids complex (MSCs–PEs) to apply on the wound surface, according to the principle of 1 mL/10 cm2, once a day for 4 weeks. The Bates–Jensen Wound Assessment Tool (BWAT) was used to assess at weeks 0 to 4 of the treatment cycle. Results: The trial was eventually completed by 44 patients. There were 22 cases in the control group and 22 cases in the treatment group. Compared with the baseline, treatment cycle of 1 to 4 weeks, a significant reduction in the treatment group BWAT score [6.5 (7.9, 5.1), P < 0.05, 11.6, 13.4, 9.9), P < 0.05; 13 (15.1, 10.9), P < 0.05; 15.6 (17.9, 13.3), P < 0.05), control group BWAT score slightly elevated [0.1 (1.2, 1.4), P > 0.05; 1.3 (0.4, 3.8), P > 0.05, 5.2, 2.8, 7.6), P > 0.05; 3.1(0.4,5.9),P > 0.05]; The difference in BWAT scores between the treatment group and the control group was significant at week 2 (-12.9(-15.9,-10.7), P < 0.05), and the difference in BWAT scores between the two groups was further expanded at week 4 (-14.3(-22.2,-15.3), P < 0.05). Conclusions: MSCs–PEs has a significant effect on the healing of chronic pressure sore wounds, and only routine dressing change is not conducive to the healing of chronic pressure sore wounds.

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