| 傅玲玲,冯炯.2型糖尿病患者TIR与脑小血管病总MRI负荷的相关性研究[J].浙江中西医结合杂志,2024,34(12): |
| 2型糖尿病患者TIR与脑小血管病总MRI负荷的相关性研究 |
| Association between TIR and total MRI burden of cerebral small-vessel disease in patients with type 2 diabetes mellitus |
| 投稿时间：2024-03-16 修订日期：2024-08-25 |
| DOI： |
| 中文关键词: 2型糖尿病 血糖在目标范围内时间 脑小血管病 总MRI负荷 |
| 英文关键词:Type 2 diabetes mellitus Time in target glucose range Cerebral small vessel diseases Total MRI burden |
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| 中文摘要: |
| 目的:研究2型糖尿病(Type 2 diabete mellitus,T2DM)患者血糖在目标范围内时间(time in range,TIR)与脑小血管病(cerebral small vessel diseases,CSVD)总MRI负荷的相关性。方法:选取2022年7月-2023年12月在浙江中医药大学附属金华中医院内分泌科住院的符合研究标准的T2DM患者60例,收集患者一般资料、生化指标,运用动态血糖监测系统(continuous glucose monitoring system,CGMS)计算出患者的TIR,根据TIR数值分为TIR达标组(n=30)与TIR未达标组(n=30),观察2组间的一般特征、实验室资料及总MRI负荷,总结TIR与CSVD总MRI负荷之间的相关性。Logistic回归分析 CSVD 总MRI负荷的影响因素。结果:与TIR达标组比较,TIR未达标组患者CSVD总MRI负荷更高(P＜0.05)。Logistic 回归分析显示,TIR、HbA1c、DM 病程是CSVD 总MRI负荷的影响因素。结论:2型糖尿病患者TIR越高,CSVD及其MRI标志物越少,在糖尿病患者的血糖管理中,除了重视HbA1c的控制,还应关注血糖的波动,TIR与CSVD的发生及严重程度密切相关。 |
| 英文摘要: |
| Objective: To explore the correlation between time in target glucose range(TIR)and total MRI burden of cerebral small vessel disease (CSVD) in patients with type 2 diabetes mellitus (T2DM). Methods: 60 T2DM patients hospitalized in Jinhua Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical University from July 2022 to December 2023 who met the research standard were selected and divided into TIR standard group (n=30) and TIR substandard group (n=30) based on the TIR value. Clinical data and total MRI burden score were collected. Analyze the correlation between TIR and the total MRI burden of CSVD. Logistic regression analysis was used to analyze the influencing factors of the total MRI burden of CSVD. Results: The total MRI burden of CSVD was higher in the TIR substandard group compared with the TIR standard group (P <0.05). Logistic Regression analysis showed that TIR, HbA1c, and DM duration were the influencing factors for the total MRI burden of CSVD. Conclusion: The higher TIR in patients with type 2 diabetes, the less CSVD and its MRI markers occured. In the glycemic management of diabetes, in addition to highlight the control of HbA1c, attention should also be paid to glycemic variability. TIR is closely related to the occurrence and severity of CSVD. |
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