| 王竞男.短暂性脑缺血发作及其危险因素与眼底动脉硬化的相关性研究[J].浙江中西医结合杂志,2025,35(1): |
| 短暂性脑缺血发作及其危险因素与眼底动脉硬化的相关性研究 |
| A study on the correlation between transient ischemic attack and its risk factors with retinal |
| 投稿时间：2024-03-17 修订日期：2024-11-28 |
| DOI： |
| 中文关键词: 短暂性脑缺血发作 危险因素 眼底动脉硬化 |
| 英文关键词:Ftransient ischemic attack Risk factors Eyeground arteriosclerosis |
| 基金项目:浙江省医药卫生科技计划项目(编号:2024XY118) |
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| 中文摘要: |
| 目的 研究短暂性脑缺血发作（TIA）及其危险因素与眼底动脉硬化的相关性。方法 选取68例因为TIA住院的病人作为这次实验的研究对象，依据其病史和临床症状将其分为TIA初发组35例，TIA多发组33例，正常对照组选取32 例相同时间段内的健康体检者。选择t检验、χ2检验和Logistic回归分析来对比研究分析这三组实验对象的糖尿病、高血压、心脏病以及眼底动脉硬化病变的发生概率，比较分析他们的血脂、血糖水平，并且研究眼底动脉硬化病变程度和TIA的关系，还有能够产生眼底动脉硬化的危险因素。结果 TIA多发组的糖尿病、高血压、心脏病发生率（54.5%、87.9%、45.5%）均高于TIA初发组（42.9%、71.4%、28.6%）和正常对照组（15.6% 、59.4% 、12.5%），差异有统计分析学研究意义（P＜0.05）。TIA初发组与TIA多发组里面的空腹血糖水平（FPG）、总胆固醇（TC）[（6.00±2.00）、（5.50±1.00）、（6.50±2.22）、（6.57±0.91）mmol/ L]均高于正常对照组[（4.26±2.27）、（4.32±0.93）mmol/L]，差异都存在统计学研究意义（P＜0.01）。TIA多发组中各个级别的的眼底动脉硬化病变的产生概率（96.7%、93.9%、87.9%、48.5%）均要高于TIA初发组（88.6%、85.7%、80.0%、31.4%）和正常对照组（68.8%、31.3%、9.4%、0），差异有统计分析学研究意义（P＜0.05）。logistic回归分析可见眼底动脉硬化Ⅲ级改变和TIA多发有关系（P＜0.05）。糖尿病和高血压二者都是眼底动脉硬化改变的独立影响因子。结论 TIA和它的危险因素与眼底动脉硬化之间是有关联的。眼底动脉硬化有助于判断TIA发作及其发作频次。 |
| 英文摘要: |
| Objective Study the correlation between the degree of retinal arteriosclerosis and the occurrence of transient ischemic attack (TIA) in patients. Methods 68 patients hospitalized for TIA were selected as the study subjects, and were divided into a TIA initial group of 35 cases and a TIA multiple group of 33 cases based on their medical history and clinical symptoms. At the same time, 32 healthy individuals who underwent physical examinations during the same period were selected as the normal control group. Select t-test χ2 Test and Logistic regression analysis were used to compare the incidence of diabetes, hypertension, heart disease and fundus vascular disease in the three groups, compare the blood lipid and blood sugar levels, and analyze the relationship between the degree of fundus arteriosclerosis and TIA, as well as the risk factors of fundus arteriosclerosis. Results The incidence of diabetes, hypertension and heart disease （54.5%、87.9%、45.5%） in the multiple TIA group was higher than that in the initial TIA group （42.9%、71.4%、28.6%） and the normal control group （15.6% 、59.4% 、12.5%）, with statistical significance (all P<0.05).The FPG and TC [(6.00 ± 2.00), (5.50 ± 1.00), (6.50 ± 2.22), and (6.57 ± 0.91) mmol/L] of the TIA initial group and TIA multiple group were higher than those of the normal control group [(4.26 ± 2.27), (4.32 ± 0.93) mmol/L], and the differences were statistically significant (all P<0.01).In the TIA multiple group, the incidence of retinal arteriosclerosis at all levels （96.7%、93.9%、87.9%、48.5%） was higher than that in the TIA initial group（88.6%、85.7%、80.0%、31.4%）and the normal control group （68.8%、31.3%、9.4%、0）, with statistical significance (P<0.05).Logistic regression analysis showed that grade III lesions of retinal arteriosclerosis were associated with multiple TIAs (P<0.05).Diabetes and hypertension are independent influencing factors of eyeground arteriosclerosis. Conclusion There is a correlation between retinal arteriosclerosis and TIA.Fundus arteriosclerosis helps to determine the frequency of TIA attacks. |
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