| 邓小梅.化痰祛湿方定向透药联合隔日禁食法治疗痰湿体质肥胖的疗效观察[J].浙江中西医结合杂志,2024,34(12): |
| 化痰祛湿方定向透药联合隔日禁食法治疗痰湿体质肥胖的疗效观察 |
| Clinical efficacy of directional penetration of traditional Chinese medicine of Huatan Qushi Fang combined with alternate day fasting on phlegm dampness obesity |
| 投稿时间：2024-03-31 修订日期：2024-11-12 |
| DOI： |
| 中文关键词: 外治法 隔日禁食 控制体质量 肥胖，痰湿体质 |
| 英文关键词:External therapy alternate day fasting Control body mass Obesity,Phlegm dampness constitution |
| 基金项目: |
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| 中文摘要: |
| 目的：观察化痰祛湿方定向透药联合隔日禁食法治疗痰湿体质肥胖的临床疗效。方法：选取2022年06月至2023年04月我院收治的120例痰湿肥胖患者，采用倾向性评分匹配（PSM）将受试者分为研究组与对照组，每组60例。对照组单纯隔日禁食4周，研究组自拟化痰祛湿方定向透药联合隔日禁食4周。比较两组受试者治疗前后的一般资料（体质量（Wt）、体质指数（BMI）、脂肪率（BF）及腰臀比（WHR））、自觉饥饿强度评分（HS），评价治疗前、后2组临床疗效及血清学指标。并统计治疗过程中出现的不良反应、中止试验人数及复发评价。结果：研究组不良反应的发生率为13.33%（8/60），低于对照组不良反应发生率为28.33%（17/60）（P＜0.05）；2组试验中止率分别为10.00%（6/60）、11.67%（7/60）（P＞0.05）；2组治疗后体质量、BMI、脂肪率及腰臀比、自觉饥饿强度评分均降低，且研究组治疗后体质量、BMI、脂肪率及腰臀比、自觉饥饿强度评分明显低于对照组（P<0.05）；研究组总有效率为90.74%明显高于对照组75.47%（P＜0.05）；2组治疗后TC、TG、LDL-C水平均明显降低，HDL-C水平明显升高，且研究组治疗后TC、TG、LDL-C水平明显低于对照组（P＜0.05），HDL-C水平明显高于对照组（P＜0.05）；随访期间研究组复发率1.85%（1/54）低于对照组复发率11.32%（6/53）（P＜0.05）。结论：化痰祛湿方定向透药联合隔日禁食法能有效降低痰湿体质肥胖患者饥饿感，改善Ws、BMI、BF%、WHR，减脂效果明显，不良反应发生率低，不容易复发，值得临床推广。 |
| 英文摘要: |
| Objective To investigate the clinical effect of directional penetration of traditional Chinese medicine of Huatan Qushi Fang combined with alternate day fasting on phlegm dampness obesity.Methods From June 2022 to April 2023, 120 patients with phlegm dampness obesity were selected and divided into two groups according to propensity score matching, 60 cases in each group.The control group received alternate day fasting for 4 weeks, and on the basis of the control group, the research group combined with directional penetration of traditional Chinese medicine of Huatan Qushi Fang. Compare the general data ( Weight, body mass index , fat percentage, and waist to hip ratio) and the hunger scale of two groups before and after treatment; Evaluate the clinical efficacy and analysis serological indicators of two groups before and after treatment; Adverse reaction and the termination rates and recurrence rate was reported and recorded.Results The adverse reactions in the study group was 13.33% (8/60), which was lower than the incidence of adverse reactions in the research group was 28.33% (17/60) (P<0.05); The termination rates of the two groups of experiments were 10.00% (6/60) and 11.67% (7/60) (P>0.05); The body mass, BMI, fat percentage, waist hip ratio, and perceived hunger intensity score decreased in both groups, and the body mass, BMI, fat percentage, waist hip ratio, and perceived hunger intensity score in the research group were significantly lower than the control group (P<0.05); The effective of the research group was 90.74%, was significantly higher than the control group was 75.47% (P<0.05); The levels of TC, TG, and LDL-C were significantly reduced in both groups, and the levels of HDL-C were significantly increased. Moreover, the levels of TC, TG, and LDL-C in the research group were significantly lower than the control group (P<0.05), while the levels of HDL-C were significantly higher than the control group (P<0.05); During the follow-up, the recurrence rate in the research group was 1.85% (1/54) lower than the control group was 11.32% (6/53) (P<0.05).Conclusion The directional penetration of traditional Chinese medicine of Huatan Qushi Fang combined with alternate day fasting can effectively reduce hunger in obese patients with phlegm dampness constitution, improve body mass, abdominal circumference, BMI, fat percentage, WHR, and have a significant fat reduction effect. Low incidence of adverse reactions and less recurrence and worth popularizing. |
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