| 施旌,余敏,任沾.马来酸曲美布汀联合莫沙比利对功能性消化不良患者胃肠动力学及血清NPSR-1、CGRP、5-HT水平的影响[J].浙江中西医结合杂志,2024,34(12): |
| 马来酸曲美布汀联合莫沙比利对功能性消化不良患者胃肠动力学及血清NPSR-1、CGRP、5-HT水平的影响 |
| Effects of trimebutine maleate combined with mosapride on gastrointestinal dynamics and serum levels of NPSR-1, CGRP and 5-HT in patients with functional dyspepsia |
| 投稿时间：2024-04-09 修订日期：2024-11-06 |
| DOI： |
| 中文关键词: 功能性消化不良 马来酸曲美布汀 莫沙比利 胃肠动力学 |
| 英文关键词:Functional dyspepsia Trimebutine maleate Mosapride Gastrointestinal dynamics |
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| 中文摘要: |
| 目的 探讨功能性消化不良患者予以马来酸曲美布汀治疗（在莫沙比利的基础上）对患者胃肠动力学、疾病相关因子的改善作用。方法 选取功能性消化不良患者为研究对象（均源于本院，选例时间：2022年10月至2023年10月），共196例，将其纳入研究后以随机数字表法作为分组原则，分为两组：对照组（98例，常规治疗+莫沙比利治疗）、观察组（98例，常规治疗+莫沙比利+马来酸曲美布汀治疗）。两组均连续治疗4周。比较两组临床疗效（治疗后），胃电图参数、胃肠道症状分级量表（GSRS）评分、胃肠动力学、胃肠激素、血清降钙素基因相关肽（CGRP）、神经肽S受体1（NPSR-1）、5-羟色胺（5-HT）水平（治疗前后），以及不良反应（治疗期间）。结果 观察组总有效率89.80%较高（组间治疗后比较，对照组为71.43%）；两组GSRS评分、血清5-HT、CGRP水平、胃电节律紊乱百分比降低（治疗后，相较于治疗前），且观察组更低（组间比较）；两组正常慢波百分比、血清胃泌素（GAS）、胃动素（MTL）、NPSR-1水平及胃窦运动指数、收缩频率、收缩幅度升高（治疗后，相较于治疗前），且观察组更高（组间比较）；两组胃半排空时间缩短（治疗后，相较于治疗前），且观察组更短（组间比较），P<0.05。结论 功能性消化不良患者予以马来酸曲美布汀治疗（在莫沙比利的基础上）可有效改善其胃电图参数、胃肠动力学，调节胃肠激素水平，进而可提高治疗效果，促进病情好转，且安全性良好。 |
| 英文摘要: |
| Objective To investigate the improvement of gastrointestinal motility and disease-related factors in patients with functional dyspepsia treated with trimebutine maleate (on the basis of mosapride). Methods A total of 196 patients with functional dyspepsia were selected as the research objects (all from our hospital, from October 2022 to October 2023).. After inclusion in the study, they were divided into two groups according to the random number table method : the control group ( 98 cases, conventional treatment + mosapride treatment ) and the observation group ( 98 cases, conventional treatment + mosapride + trimebutine maleate treatment ). Both groups were treated for 4 weeks. The clinical efficacy (after treatment), electrogastrogram parameters, gastrointestinal symptom rating scale (GSRS) score, gastrointestinal dynamics, gastrointestinal hormones, serum calcitonin gene-related peptide (CGRP), neuropeptide S receptor 1 (NPSR-1), 5-hydroxytryptamine (5-HT) levels (before and after treatment), and adverse reactions (during treatment) were compared between the two groups.. Results The total effective rate of the observation group was 89.80 % higher (after treatment, the control group was 71.43 %). the GSRS score, percentage of gastric electrical rhythm disorder, serum 5-HT and CGRP levels of the two groups decreased (After treatment, compared to before treatment), and those of the observation group were lower (comparison between groups) ; the percentage of normal slow wave, serum gastrin (GAS), motilin (MTL), NPSR-1 level, gastric antrum motility index, contraction frequency, contraction amplitude of the two groups increased (After treatment, compared to before treatment), and those of the observation group were higher (comparison between groups) ; the gastric half emptying time of the two groups shortened ( After treatment, compared to before treatment ), and that of the observation group was shorter (comparison between groups), P<0.05. Conclusion The treatment of patients with functional dyspepsia with trimebutine maleate ( on the basis of mosapride ) can effectively improve their electrogastrogram parameters, gastrointestinal dynamics, and regulate gastrointestinal hormone levels, thereby improving the therapeutic effect and promoting the improvement of the disease, and the safety is good.. |
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