| 舒婷,周俊,赵昕峰,丁娟,吴亦栋.杭州住院儿童急性呼吸道感染病原学流行新特征[J].浙江中西医结合杂志,2024,34(11): |
| 杭州住院儿童急性呼吸道感染病原学流行新特征 |
| New Features in the Epidemiology of Pathogens Causing Acute Respiratory Infections in Hospitalized Children in Hangzhou |
| 投稿时间：2024-04-17 修订日期：2024-10-30 |
| DOI： |
| 中文关键词: 儿童 急性呼吸道感染 呼吸道病原体 非药物管控措施 |
| 英文关键词:Children Acute respiratory infections Respiratory pathogens Non-pharma-ceutical interventions |
| 基金项目:浙江省医药卫生科技项目(2022KY1011) |
|
| 摘要点击次数: 332 |
| 全文下载次数: 2 |
| 中文摘要: |
| 目的 通过对杭州地区在非药物管控措施（non-pharma-ceutical interventions，NPIs ）解除后的第一年儿童常见呼吸道病原体流行病学的研究，了解引起杭州地区儿童呼吸道疾病流行的病原学特征。方法 回顾性研究选取我国NPIs解除后2022年12月至2023年11月在杭州市儿童医院住院的8730例急性呼吸道感染（Acute respiratory infection，ARI）患者作为研究对象，采用PCR荧光探针法对肺炎支原体（mycoplasma pneumoniae，MP）、呼吸道合胞病毒（respiratory syncytial virus，RSV）、甲型流感病毒（influenza virus A，FluA）、副流感病毒3型（parainfluenza virus type 3，PIV-3）、腺病毒（adenovirus，ADV）、副流感病毒1型（parainfluenza virus type 1，PIV-1）、乙型流感病毒（Influenza virus B，FluB）核酸进行检测，采用卡方检验对分析结果。结果 8730例ARI患儿标本中共检出病原体4507例（51.63%，4507/8730），检出率最高的前三种病原体依次为MP 30.15%（2632/8730），RSV 12.20%（1065/8730）和FluA 7.81%（682/8730）。RSV、PIV-3检出率都随着年龄的增长逐渐降低，<1岁患儿检出最高，7-16岁检出最低。MP则相反，检出率随着年龄增长逐渐升高，且女童比男童更易感染MP，差异有统计学意义（χ2=5.73，P<0.05）。7种呼吸道病原体在秋季和夏季检出最高，其中夏季流行MP、RSV和PIV-3，秋季流行MP，春季流行FluA，冬季流行RSV和FluA。FluA和ADV主要引起儿童上呼吸道感染，PIV-3、RSV和MP主要引起下呼吸道感染。结论NPIs解除后的杭州地区儿童呼吸道病原体流行以MP、RSV和FluA为主，不同病原体检出率在流行季节、年龄分布及临床诊断等方面都不同。 |
| 英文摘要: |
| Objective Through the study of the epidemiology of common respiratory pathogens in children in Hangzhou in the first year after withdrawal of NPIs measures, we aimed to understand the etiological characteristics of the outbreak of respiratory diseases in children in Hangzhou. Methods A retrospective study was conducted on 8730 ARI patients who were treated in Hangzhou Children's Hospital from December 2022 to November 2023 after withdrawal of NPIs measures in China. Influenza virus A (FluA), influenza virus B (FluB), parainfluenza virus type 1 (PIV-1), parainfluenza virus type 3 (PIV-3), respiratory syncytial virus (RSV), adenovirus (ADV), and Mycoplasma pneumoniae (MP) were detected by PCR fluorescence probe method. The results were analyzed by the chi-square test. result A total of 4507(51.63%, 4507/8730) cases of pathogens were detected in 8730 ARI specimens , and the top three pathogens were MP 30.15% (2632/8730), RSV 12.20%（1065/8730）, and FluA 7.81% (682/8730). The detection rates of RSV and PIV-3 gradually decreased with age, with the highest detection rate in children <1 year old and the lowest detection rate in children 7-16 years old. MP was opposite, the detection rate gradually increased with age, and girls were more likely to be infected with MP than boys, with a statistically significant difference (χ2=5.73, P<0.05). The seven respiratory pathogens were detected in autumn and summer, among which MP, RSV and PIV-3 were prevalent in summer, MP was prevalent in autumn, FluA was prevalent in spring, and RSV and FluA were prevalent in winter. FluA and ADV mainly caused upper respiratory tract infections in children, while PIV-3, RSV and MP mainly caused lower respiratory tract infections. Conclusion After withdrawal of NPIs measures, MP, RSV and FluA are the main respiratory pathogens in children in Hangzhou , and the detection rates of different pathogens epidemic are different in season, age distribution and clinical diagnosis. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |
|
|
|
