| 祁佩红,梁家绪,李四保,刘志敏,樊佳.慢性阻塞性肺疾病稳定期中医证型与肺功能的相关性分析[J].浙江中西医结合杂志,2025,35(1): |
| 慢性阻塞性肺疾病稳定期中医证型与肺功能的相关性分析 |
| The correlation analysis between traditional Chinese medicine syndromes and pulmonary function in stable COPD |
| 投稿时间：2024-04-18 修订日期：2024-12-12 |
| DOI： |
| 中文关键词: 慢性阻塞性肺疾病 稳定期 中医证型 肺功能 |
| 英文关键词:Chronic obstructive pulmonary disease Stable phase Chinese medicine syndrome Pulmonary function |
| 基金项目:河南省医学科技攻关计划(联合共建)项目(LHGJ20191092) |
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| 中文摘要: |
| 目的 探讨慢性阻塞性肺疾病（COPD）稳定期中医证型与肺功能的相关性。方法 收集2019年12月至2023年9月在我院呼吸科就诊的86例稳定期COPD患者。收集患者年龄、性别、BMI等资料；所有患者均行中医证型分型、肺功能检查，并进行肺功能分级。结果 86例患者有肺气虚型32例，肺脾气虚型32例，肺肾气虚型22例。三种中医证型在体重、BMI以FVC、FEV1、FEV1/FVC、FEV1%上存在统计学差异（P<0.05），且FVC、FEV1、FEV1/FVC、FEV1%按肺气虚型、肺脾气虚型、肺肾气虚型顺序逐渐减小，FEV1/FVC、FEV1%为中医证型分类的独立因素，与中医证型呈负相关（B<0，P<0.05）。在肺功能分级上，肺气虚型Ⅰ级患者比例（46.88%）明显高于肺脾气虚和肺肾气虚型（P<0.05）；肺气虚型和肺脾气虚Ⅱ级患者比例（均46.88%）也明显高于肺肾气虚型（9.09）（P<0.05）；肺气虚型Ⅲ、Ⅳ级患者比例明显低于肺脾气虚和肺肾气虚型（P<0.05）；且中医证型与肺功能分级呈明显正相关（r=0.725，P<0.05）。结论 COPD稳定期中医证型与肺功能指标、肺功能分级存在明显相关性，肺功能检查可为COPD稳定期中医分型提供客观依据。 |
| 英文摘要: |
| Objective To investigate the correlation between traditional Chinese medicine syndromes (TCM) and pulmonary function in stable chronic obstructive pulmonary disease (COPD). Methods A total of 86 patients with stable COPD who visited the respiratory department of our hospital from December 2019 to September 2023 were collected. Patients' age, gender, BMI and other general information were collected. All patients underwent TCM classification and pulmonary function examination, and pulmonary function grading. Results Among the 86 patients, there were 32 cases of lung-qi deficiency, 32 cases of lung-qi deficiency and 22 cases of lung-kidney qi deficiency. There were statistical differences in body weight and BMI among the three TCM syndrome types in terms of FVC, FEV1, FEV1/FVC and FEV1% (P<0.05), and FVC, FEV1, FEV1/FVC and FEV1% gradually decreased according to the order of lung-qi deficiency, lung-qi deficiency and lung-kidney qi deficiency. FEV1/FVC and FEV1% were independent factors of TCM syndrome type classification, and were negatively correlated with TCM syndrome type (B<0, P<0.05). In the classification of lung function, the proportion of grade I patients with lung Qi deficiency type (46.88%) was significantly higher than those with lung qi deficiency and lung kidney qi deficiency type (P<0.05). The proportion of lung qi deficiency type and lung Qi deficiency type Ⅱ patients (all 46.88%) was significantly higher than that of lung and kidney qi deficiency type (9.09%) (P<0.05). The proportion of lung qi deficiency type Ⅲ, Ⅳ patients was significantly lower than lung qi deficiency type and lung kidney qi deficiency type (P<0.05). There was a significant positive correlation between TCM syndrome type and lung function grade (r=0.725, P<0.05). Conclusion There is a significant correlation between the TCM syndrome in stable COPD and pulmonary function parameters and pulmonary function grading. Pulmonary function examination can provide objective basis for TCM classification in stable COPD. |
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